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- W1990329100 abstract "Thyroid hormone (T3) can trigger a massive differentiation of cultured oligodendrocytes precursor cells (OPC) by binding the nuclear T3 receptor α1 (TRα1). Whether this reflects a physiological function of TRα1 remains uncertain. Using a recently generated mouse model, in which CRE/loxP recombination is used to block its function, we show that TRα1 acts at two levels for the in vivo differentiation of OPC in mouse cerebellum. At the early postnatal stage, it promotes the secretion of several neurotrophic factors by acting in Purkinje neurons and astrocytes, defining an environment suitable for OPC differentiation. At later stages, TRα1 acts in a cell-autonomous manner to ensure the complete arrest of OPC proliferation. These data explain contradictory observations made on various models and outline the importance of T3 signaling both for synchronizing postnatal neurodevelopment and restraining OPC proliferation in adult brain." @default.
- W1990329100 created "2016-06-24" @default.
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- W1990329100 date "2012-04-01" @default.
- W1990329100 modified "2023-10-11" @default.
- W1990329100 title "A Bimodal Influence of Thyroid Hormone on Cerebellum Oligodendrocyte Differentiation" @default.
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- W1990329100 doi "https://doi.org/10.1210/me.2011-1316" @default.
- W1990329100 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5417134" @default.
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