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- W1990331450 abstract "Stem cell-based regenerative therapy is a promising treatment for head and neck cancer patients that suffer from chronic dry mouth (xerostomia) due to salivary gland injury from radiation therapy. Current xerostomia therapies only provide temporary symptom relief, while permanent restoration of salivary function is not currently feasible. Here, we identified and characterized a stem cell population from adult murine submandibular glands. Of the different cells isolated from the submandibular gland, this specific population, Lin-CD24+c-Kit+Sca1+, possessed the highest capacity for proliferation, self renewal, and differentiation during serial passage in vitro. Serial transplantations of this stem cell population into the submandibular gland of irradiated mice successfully restored saliva secretion and increased the number of functional acini. Gene-expression analysis revealed that glial cell line-derived neurotrophic factor (Gdnf) is highly expressed in Lin-CD24+c-Kit+Sca1+ stem cells. Furthermore, GDNF expression was upregulated upon radiation therapy in submandibular glands of both mice and humans. Administration of GDNF improved saliva production and enriched the number of functional acini in submandibular glands of irradiated animals and enhanced salisphere formation in cultured salivary stem cells, but did not accelerate growth of head and neck cancer cells. These data indicate that modulation of the GDNF pathway may have potential therapeutic benefit for management of radiation-induced xerostomia." @default.
- W1990331450 created "2016-06-24" @default.
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- W1990331450 date "2014-07-18" @default.
- W1990331450 modified "2023-10-12" @default.
- W1990331450 title "Neurotrophic factor GDNF promotes survival of salivary stem cells" @default.
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- W1990331450 cites W1980348526 @default.
- W1990331450 cites W1983517713 @default.
- W1990331450 cites W1984225599 @default.
- W1990331450 cites W1989244336 @default.
- W1990331450 cites W1989331780 @default.
- W1990331450 cites W1989381407 @default.
- W1990331450 cites W1990349606 @default.
- W1990331450 cites W1992881979 @default.
- W1990331450 cites W1993154073 @default.
- W1990331450 cites W1993696122 @default.
- W1990331450 cites W1997716402 @default.
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- W1990331450 cites W2002170709 @default.
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- W1990331450 cites W2015607265 @default.
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- W1990331450 cites W2026061437 @default.
- W1990331450 cites W2026537737 @default.
- W1990331450 cites W2038780641 @default.
- W1990331450 cites W2041425187 @default.
- W1990331450 cites W2052962218 @default.
- W1990331450 cites W2054810445 @default.
- W1990331450 cites W2057014510 @default.
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- W1990331450 cites W2065173028 @default.
- W1990331450 cites W2067998137 @default.
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- W1990331450 cites W2071432029 @default.
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- W1990331450 cites W2094774201 @default.
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- W1990331450 cites W2096252347 @default.
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- W1990331450 cites W2101736621 @default.
- W1990331450 cites W2103212285 @default.
- W1990331450 cites W2107838455 @default.
- W1990331450 cites W2107988120 @default.
- W1990331450 cites W2111471439 @default.
- W1990331450 cites W2111724542 @default.
- W1990331450 cites W2119556372 @default.
- W1990331450 cites W2123371637 @default.
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- W1990331450 cites W2135427112 @default.
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- W1990331450 cites W2143498768 @default.
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- W1990331450 doi "https://doi.org/10.1172/jci74096" @default.
- W1990331450 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4109543" @default.
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