Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990332595> ?p ?o ?g. }
- W1990332595 endingPage "140" @default.
- W1990332595 startingPage "131" @default.
- W1990332595 abstract "Mitotic kinesin-like protein 2 (MKlp2), a microtubule-associated motor, is required during mitosis exit for the final step of cytokinesis. It also contributes to retrograde vesicular trafficking from the Golgi apparatus to the endoplasmic reticulum in interphase. The KIF20A gene encoding MKlp2 is controlled by the E2F-retinoblastoma protein-p16 pathway, and its widely expressed mRNA is found in fetal and proliferating adult tissues. The expression pattern and function of MKlp2 in the adult liver, however, have not been investigated. We report herein that MKlp2 transiently accumulates in vivo during mouse liver regeneration after partial hepatectomy and is strongly overexpressed in preneoplastic and neoplastic mouse liver. In vitro in mitogen-stimulated primary hepatocytes, MKlp2 accumulated in the nucleus during the G2 phase of the cell cycle coincident with the mitotic kinase Aurora B. Human hepatoma cell lines exhibited high levels of MKlp2; however, it was undetectable in normal human hepatocytes. RNAi-mediated MKlp2 knockdown in hepatoma cells induced polyploidization consistent with its essential function in promoting cytokinesis and inhibited cell proliferation without inducing apoptosis. KIF20A mRNA was strongly accumulated in a large series of human hepatocellular carcinomas, with the highest expression observed in tumors with genomic instability. Accumulation of MKlp2 in normal proliferating, preneoplastic, and transformed hepatocytes suggests that MKlp2 contributes to both normal and pathologic hepatocyte proliferation and is linked to tumor aggressiveness in human hepatocellular carcinomas." @default.
- W1990332595 created "2016-06-24" @default.
- W1990332595 creator A5031325544 @default.
- W1990332595 creator A5031773674 @default.
- W1990332595 creator A5041662580 @default.
- W1990332595 creator A5044275856 @default.
- W1990332595 creator A5047055772 @default.
- W1990332595 creator A5048338669 @default.
- W1990332595 creator A5055995633 @default.
- W1990332595 creator A5064701366 @default.
- W1990332595 creator A5069325064 @default.
- W1990332595 creator A5074609427 @default.
- W1990332595 date "2012-01-01" @default.
- W1990332595 modified "2023-10-15" @default.
- W1990332595 title "KIF20A mRNA and Its Product MKlp2 Are Increased During Hepatocyte Proliferation and Hepatocarcinogenesis" @default.
- W1990332595 cites W1963769227 @default.
- W1990332595 cites W1979685062 @default.
- W1990332595 cites W1992588067 @default.
- W1990332595 cites W1997179110 @default.
- W1990332595 cites W1998809103 @default.
- W1990332595 cites W2005096897 @default.
- W1990332595 cites W2023815439 @default.
- W1990332595 cites W2032330856 @default.
- W1990332595 cites W2034091087 @default.
- W1990332595 cites W2036270511 @default.
- W1990332595 cites W2038745712 @default.
- W1990332595 cites W2038783205 @default.
- W1990332595 cites W2040758686 @default.
- W1990332595 cites W2041575284 @default.
- W1990332595 cites W2049425734 @default.
- W1990332595 cites W2055342169 @default.
- W1990332595 cites W2069643337 @default.
- W1990332595 cites W2070326039 @default.
- W1990332595 cites W2072683008 @default.
- W1990332595 cites W2073754955 @default.
- W1990332595 cites W2076306878 @default.
- W1990332595 cites W2084261216 @default.
- W1990332595 cites W2094502141 @default.
- W1990332595 cites W2100096634 @default.
- W1990332595 cites W2107277218 @default.
- W1990332595 cites W2107840687 @default.
- W1990332595 cites W2118025453 @default.
- W1990332595 cites W2119834455 @default.
- W1990332595 cites W2122401755 @default.
- W1990332595 cites W2125247503 @default.
- W1990332595 cites W2125306062 @default.
- W1990332595 cites W2131879548 @default.
- W1990332595 cites W2134053713 @default.
- W1990332595 cites W2139025111 @default.
- W1990332595 cites W2157881623 @default.
- W1990332595 cites W2162612570 @default.
- W1990332595 cites W4254164242 @default.
- W1990332595 doi "https://doi.org/10.1016/j.ajpath.2011.09.040" @default.
- W1990332595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22056911" @default.
- W1990332595 hasPublicationYear "2012" @default.
- W1990332595 type Work @default.
- W1990332595 sameAs 1990332595 @default.
- W1990332595 citedByCount "61" @default.
- W1990332595 countsByYear W19903325952012 @default.
- W1990332595 countsByYear W19903325952014 @default.
- W1990332595 countsByYear W19903325952015 @default.
- W1990332595 countsByYear W19903325952016 @default.
- W1990332595 countsByYear W19903325952017 @default.
- W1990332595 countsByYear W19903325952018 @default.
- W1990332595 countsByYear W19903325952019 @default.
- W1990332595 countsByYear W19903325952020 @default.
- W1990332595 countsByYear W19903325952021 @default.
- W1990332595 countsByYear W19903325952022 @default.
- W1990332595 countsByYear W19903325952023 @default.
- W1990332595 crossrefType "journal-article" @default.
- W1990332595 hasAuthorship W1990332595A5031325544 @default.
- W1990332595 hasAuthorship W1990332595A5031773674 @default.
- W1990332595 hasAuthorship W1990332595A5041662580 @default.
- W1990332595 hasAuthorship W1990332595A5044275856 @default.
- W1990332595 hasAuthorship W1990332595A5047055772 @default.
- W1990332595 hasAuthorship W1990332595A5048338669 @default.
- W1990332595 hasAuthorship W1990332595A5055995633 @default.
- W1990332595 hasAuthorship W1990332595A5064701366 @default.
- W1990332595 hasAuthorship W1990332595A5069325064 @default.
- W1990332595 hasAuthorship W1990332595A5074609427 @default.
- W1990332595 hasBestOaLocation W19903325951 @default.
- W1990332595 hasConcept C1491633281 @default.
- W1990332595 hasConcept C158617107 @default.
- W1990332595 hasConcept C171056886 @default.
- W1990332595 hasConcept C173396325 @default.
- W1990332595 hasConcept C190283241 @default.
- W1990332595 hasConcept C202751555 @default.
- W1990332595 hasConcept C2776200302 @default.
- W1990332595 hasConcept C2776795407 @default.
- W1990332595 hasConcept C29537977 @default.
- W1990332595 hasConcept C45472230 @default.
- W1990332595 hasConcept C502942594 @default.
- W1990332595 hasConcept C54355233 @default.
- W1990332595 hasConcept C55493867 @default.
- W1990332595 hasConcept C62112901 @default.
- W1990332595 hasConcept C85813293 @default.
- W1990332595 hasConcept C86803240 @default.
- W1990332595 hasConcept C93304396 @default.