FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990332604> ?p ?o ?g. }

• W1990332604 endingPage "1491" @default.
• W1990332604 startingPage "1483" @default.
• W1990332604 abstract "Whole cell pertussis (wP) vaccines are gradually being replaced by aluminum salt-adjuvanted acellular pertussis (aP) vaccines. These promote CD4+ T cell responses with a non-protective Th2 component, while protective immune mechanisms to B. pertussis may rather involve long-lived Th1/Th17 type CD4+ T cells. Here we asked whether addition of a non-toxic meningococcal LPS derivative, LpxL1, as adjuvant can favorably modulate the aP-induced pertussis-specific CD4+ T cell response in mice. To assess the effect of TLR4 ligation, Th type, quantity, and memory potential of pertussis-specific CD4+ T cells were determined at the single-cell level after aP and aP+LpxL1 vaccination using intracellular cytokine staining and MHC class II tetramers. Adding LpxL1 to the aP vaccine weakened the Th2 component and strengthened the Th1/Th17 component of the specific CD4+ T cell response. Notably, LpxL1 addition also induced higher frequencies of tetramer positive CD4+ T cells in draining lymph nodes or blood, depending on the phase after vaccination. Moreover, there was a net profit in the number of CD4+ T cells with a central memory phenotype, preferred for long-term immunity. Thus, adding a TLR4 ligand as adjuvant to a current aP vaccine was associated with a more favorable pertussis-specific CD4+ T cell response." @default.
• W1990332604 created "2016-06-24" @default.
• W1990332604 creator A5007836143 @default.
• W1990332604 creator A5022402099 @default.
• W1990332604 creator A5041427551 @default.
• W1990332604 creator A5047341769 @default.
• W1990332604 creator A5067058142 @default.
• W1990332604 creator A5080245057 @default.
• W1990332604 creator A5083836303 @default.
• W1990332604 date "2015-03-01" @default.
• W1990332604 modified "2023-09-27" @default.
• W1990332604 title "Modulation of the CD4+ T cell response after acellular pertussis vaccination in the presence of TLR4 ligation" @default.
• W1990332604 cites W1941562760 @default.
• W1990332604 cites W1978903184 @default.
• W1990332604 cites W1981480494 @default.
• W1990332604 cites W1985294654 @default.
• W1990332604 cites W1987628377 @default.
• W1990332604 cites W2002478231 @default.
• W1990332604 cites W2006778110 @default.
• W1990332604 cites W2006985918 @default.
• W1990332604 cites W2010202371 @default.
• W1990332604 cites W2012680181 @default.
• W1990332604 cites W2026400165 @default.
• W1990332604 cites W2036463856 @default.
• W1990332604 cites W2038230881 @default.
• W1990332604 cites W2042045439 @default.
• W1990332604 cites W2057706962 @default.
• W1990332604 cites W2073997553 @default.
• W1990332604 cites W2092607772 @default.
• W1990332604 cites W2093313081 @default.
• W1990332604 cites W2093901235 @default.
• W1990332604 cites W2094991613 @default.
• W1990332604 cites W2102784438 @default.
• W1990332604 cites W2107235439 @default.
• W1990332604 cites W2107578451 @default.
• W1990332604 cites W2113847305 @default.
• W1990332604 cites W2119310382 @default.
• W1990332604 cites W2127391370 @default.
• W1990332604 cites W2127921247 @default.
• W1990332604 cites W2131748930 @default.
• W1990332604 cites W2134702933 @default.
• W1990332604 cites W2138813182 @default.
• W1990332604 cites W2142190116 @default.
• W1990332604 cites W2144498998 @default.
• W1990332604 cites W2152385842 @default.
• W1990332604 cites W2154202775 @default.
• W1990332604 cites W2158142793 @default.
• W1990332604 cites W2158153166 @default.
• W1990332604 cites W2161426250 @default.
• W1990332604 cites W2167823242 @default.
• W1990332604 cites W2170904230 @default.
• W1990332604 doi "https://doi.org/10.1016/j.vaccine.2015.01.063" @default.
• W1990332604 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25659267" @default.
• W1990332604 hasPublicationYear "2015" @default.
• W1990332604 type Work @default.
• W1990332604 sameAs 1990332604 @default.
• W1990332604 citedByCount "31" @default.
• W1990332604 countsByYear W19903326042015 @default.
• W1990332604 countsByYear W19903326042016 @default.
• W1990332604 countsByYear W19903326042017 @default.
• W1990332604 countsByYear W19903326042018 @default.
• W1990332604 countsByYear W19903326042019 @default.
• W1990332604 countsByYear W19903326042020 @default.
• W1990332604 countsByYear W19903326042021 @default.
• W1990332604 countsByYear W19903326042022 @default.
• W1990332604 countsByYear W19903326042023 @default.
• W1990332604 crossrefType "journal-article" @default.
• W1990332604 hasAuthorship W1990332604A5007836143 @default.
• W1990332604 hasAuthorship W1990332604A5022402099 @default.
• W1990332604 hasAuthorship W1990332604A5041427551 @default.
• W1990332604 hasAuthorship W1990332604A5047341769 @default.
• W1990332604 hasAuthorship W1990332604A5067058142 @default.
• W1990332604 hasAuthorship W1990332604A5080245057 @default.
• W1990332604 hasAuthorship W1990332604A5083836303 @default.
• W1990332604 hasConcept C126322002 @default.
• W1990332604 hasConcept C170493617 @default.
• W1990332604 hasConcept C203014093 @default.
• W1990332604 hasConcept C22070199 @default.
• W1990332604 hasConcept C2776090121 @default.
• W1990332604 hasConcept C2777582894 @default.
• W1990332604 hasConcept C2777863537 @default.
• W1990332604 hasConcept C2779341262 @default.
• W1990332604 hasConcept C2779634000 @default.
• W1990332604 hasConcept C2780801004 @default.
• W1990332604 hasConcept C49773422 @default.
• W1990332604 hasConcept C523546767 @default.
• W1990332604 hasConcept C54355233 @default.
• W1990332604 hasConcept C71924100 @default.
• W1990332604 hasConcept C80631254 @default.
• W1990332604 hasConcept C86803240 @default.
• W1990332604 hasConcept C8891405 @default.
• W1990332604 hasConceptScore W1990332604C126322002 @default.
• W1990332604 hasConceptScore W1990332604C170493617 @default.
• W1990332604 hasConceptScore W1990332604C203014093 @default.
• W1990332604 hasConceptScore W1990332604C22070199 @default.
• W1990332604 hasConceptScore W1990332604C2776090121 @default.
• W1990332604 hasConceptScore W1990332604C2777582894 @default.
• W1990332604 hasConceptScore W1990332604C2777863537 @default.

• next