FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990332684> ?p ?o ?g. }

• W1990332684 endingPage "447" @default.
• W1990332684 startingPage "441" @default.
• W1990332684 abstract "<b><i>Summary</i></b><b><i>Background: </i></b>Osteoblast- and osteoclast-like cells are responsible for coordinated bone maintenance, illustrated by a balanced formation and resorption. Both parameters appear to be influenced by mechanical constrains acting on each of these cell types individually. We hypothesized that the interactions between both cell types are also influenced by mechanical stimulation. <b><i>Methods: </i></b>Co-cultures of osteoblast- and osteoclast-like cells were stimulated with 1,100 µstrain, 0.1 or 0.3 Hz for 1-5 min/day over 5 days. Two different setups depending on the differentiation of the osteoclast-like cells were used: i) differentiation assay for the fusion of pre-osteoclasts to osteoclasts, ii) resorption assay to determine the activity level of osteoclast-like cells. <b><i>Results: </i></b>In the differentiation assay (co-culture of osteoblasts with unfused osteoclast precursor cells) the mechanical stimulation resulted in a significant decrease of collagen-1 and osteocalcin produced by osteoblast-like cells. Significantly more TRAP-iso5b was measured after stimulation for 3 min with 0.1 Hz, indicating enhanced osteoclastogenesis. In the resorption assay (co-culture of osteoblasts with fused osteoclasts) the stimulation for 3 min with 0.3 Hz significantly increased the resorption activity of osteoclasts measured by the pit formation and the collagen resorption. The same mechanical stimulation resulted in an increased collagen-1 production by the osteoblast-like cells. The ratio of RANKL/OPG was not different between the groups. <b><i>Conclusion: </i></b>These findings demonstrate that already small changes in duration or frequency of mechanical stimulation had significant consequences for the behavior of osteoblast- and osteoclast-like cells in co-culture, which partially depend on the differentiation status of the osteoclast-like cells." @default.
• W1990332684 created "2016-06-24" @default.
• W1990332684 creator A5044544712 @default.
• W1990332684 creator A5062472974 @default.
• W1990332684 creator A5069025368 @default.
• W1990332684 creator A5069236094 @default.
• W1990332684 creator A5079184013 @default.
• W1990332684 date "2013-01-01" @default.
• W1990332684 modified "2023-10-06" @default.
• W1990332684 title "Slight Changes in the Mechanical Stimulation Affects Osteoblast- and Osteoclast-Like Cells in Co-Culture" @default.
• W1990332684 cites W1976845897 @default.
• W1990332684 cites W1979883641 @default.
• W1990332684 cites W1987187785 @default.
• W1990332684 cites W1999344049 @default.
• W1990332684 cites W2001256759 @default.
• W1990332684 cites W2006409684 @default.
• W1990332684 cites W2011494353 @default.
• W1990332684 cites W2016003140 @default.
• W1990332684 cites W2019212954 @default.
• W1990332684 cites W2032394856 @default.
• W1990332684 cites W2036679520 @default.
• W1990332684 cites W2038965450 @default.
• W1990332684 cites W2039386469 @default.
• W1990332684 cites W2041446238 @default.
• W1990332684 cites W2041537763 @default.
• W1990332684 cites W2043238627 @default.
• W1990332684 cites W2050378151 @default.
• W1990332684 cites W2060608295 @default.
• W1990332684 cites W2062966761 @default.
• W1990332684 cites W2069505287 @default.
• W1990332684 cites W2073635178 @default.
• W1990332684 cites W2081658714 @default.
• W1990332684 cites W2082396116 @default.
• W1990332684 cites W2089162996 @default.
• W1990332684 cites W2094539147 @default.
• W1990332684 cites W2102844239 @default.
• W1990332684 cites W2154216995 @default.
• W1990332684 cites W2165673443 @default.
• W1990332684 cites W2169762760 @default.
• W1990332684 doi "https://doi.org/10.1159/000356284" @default.
• W1990332684 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3901596" @default.
• W1990332684 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24474895" @default.
• W1990332684 hasPublicationYear "2013" @default.
• W1990332684 type Work @default.
• W1990332684 sameAs 1990332684 @default.
• W1990332684 citedByCount "10" @default.
• W1990332684 countsByYear W19903326842013 @default.
• W1990332684 countsByYear W19903326842015 @default.
• W1990332684 countsByYear W19903326842018 @default.
• W1990332684 countsByYear W19903326842021 @default.
• W1990332684 countsByYear W19903326842022 @default.
• W1990332684 crossrefType "journal-article" @default.
• W1990332684 hasAuthorship W1990332684A5044544712 @default.
• W1990332684 hasAuthorship W1990332684A5062472974 @default.
• W1990332684 hasAuthorship W1990332684A5069025368 @default.
• W1990332684 hasAuthorship W1990332684A5069236094 @default.
• W1990332684 hasAuthorship W1990332684A5079184013 @default.
• W1990332684 hasBestOaLocation W19903326841 @default.
• W1990332684 hasConcept C126322002 @default.
• W1990332684 hasConcept C131075544 @default.
• W1990332684 hasConcept C134018914 @default.
• W1990332684 hasConcept C146562846 @default.
• W1990332684 hasConcept C160160445 @default.
• W1990332684 hasConcept C181199279 @default.
• W1990332684 hasConcept C185592680 @default.
• W1990332684 hasConcept C202751555 @default.
• W1990332684 hasConcept C24998067 @default.
• W1990332684 hasConcept C2776033226 @default.
• W1990332684 hasConcept C2778260815 @default.
• W1990332684 hasConcept C55493867 @default.
• W1990332684 hasConcept C673006 @default.
• W1990332684 hasConcept C71924100 @default.
• W1990332684 hasConcept C86803240 @default.
• W1990332684 hasConcept C95444343 @default.
• W1990332684 hasConceptScore W1990332684C126322002 @default.
• W1990332684 hasConceptScore W1990332684C131075544 @default.
• W1990332684 hasConceptScore W1990332684C134018914 @default.
• W1990332684 hasConceptScore W1990332684C146562846 @default.
• W1990332684 hasConceptScore W1990332684C160160445 @default.
• W1990332684 hasConceptScore W1990332684C181199279 @default.
• W1990332684 hasConceptScore W1990332684C185592680 @default.
• W1990332684 hasConceptScore W1990332684C202751555 @default.
• W1990332684 hasConceptScore W1990332684C24998067 @default.
• W1990332684 hasConceptScore W1990332684C2776033226 @default.
• W1990332684 hasConceptScore W1990332684C2778260815 @default.
• W1990332684 hasConceptScore W1990332684C55493867 @default.
• W1990332684 hasConceptScore W1990332684C673006 @default.
• W1990332684 hasConceptScore W1990332684C71924100 @default.
• W1990332684 hasConceptScore W1990332684C86803240 @default.
• W1990332684 hasConceptScore W1990332684C95444343 @default.
• W1990332684 hasIssue "6" @default.
• W1990332684 hasLocation W19903326841 @default.
• W1990332684 hasLocation W19903326842 @default.
• W1990332684 hasLocation W19903326843 @default.
• W1990332684 hasLocation W19903326844 @default.
• W1990332684 hasOpenAccess W1990332684 @default.
• W1990332684 hasPrimaryLocation W19903326841 @default.
• W1990332684 hasRelatedWork W2036148628 @default.

• next