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- W1990332775 abstract "Over the past decade, protein kinase B (PKB, also termed Akt) has emerged as an important signaling mediator between extracellular cues and modulation of gene expression, metabolism, and cell survival. The enzyme is tightly controlled and consequences of its deregulation include loss of growth control and oncogenesis. Recent work has better characterized the mechanism of PKB activation, including upstream regulators and secondary binding partners. This minireview refreshes some old concepts with new twists and highlights current outstanding questions." @default.
- W1990332775 created "2016-06-24" @default.
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- W1990332775 date "2003-05-27" @default.
- W1990332775 modified "2023-10-16" @default.
- W1990332775 title "Unravelling the activation mechanisms of protein kinase B/Akt" @default.
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- W1990332775 doi "https://doi.org/10.1016/s0014-5793(03)00562-3" @default.
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