FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990333514> ?p ?o ?g. }

• W1990333514 endingPage "108" @default.
• W1990333514 startingPage "101" @default.
• W1990333514 abstract "Electroconvulsive seizures (ECS) are used for therapy of pharmacoresistent depression and are supposed to induce long-lasting neuronal alterations in morphology and gene expression. In this study, we have investigated the phosphorylation of the transcription factor protein c-Jun at its serine 73 residue by immunohistochemistry and the activity of the c-Jun N-terminal kinase 1 (JNK1) by immunocomplex assay following repetitive ECS in adult rats. In untreated controls, nuclear c-Jun immunoreactivity, but not N-terminal phosphorylation, was present in a variety of neuronal populations including the hippocampus, the temporobasal cortex and the amygdalar complex. Daily ECS for 1, 5 or 10 days (1x, 5x or 10x ECS) did not alter the expression of c-Jun but caused a substantial N-terminal phosphorylation of c-Jun (phospho-c-Jun). Nuclear phospho-c-Jun immunoreactivity was maximal within 15 min following ECS, and became absent after 30 min. The highest levels of phospho-c-Jun labeling were found after 1x ECS in the amygdalar complex, the dorsomedial hypothalamus and the piriform cortex. The inducibility of c-Jun N-terminal phosphorylation was preserved in the medial amygdala and piriform cortex, but significantly declined in the basal amygdala and medial hypothalamus with progressive ECS stimulation. One single ECS 3 or 5 days following 10x ECS yielded a pattern of phospho-c-Jun as seen following 10x ECS; thus, a lag of 5 days was not sufficient to provoke the initial level of N-terminal phosphorylation of c-Jun. In the rostral hippocampus, c-Jun was not phosphorylated at any investigated time inspite of its high constitutive expression. In some contrast with this compartment-specific phosphorylation of c-Jun, immunocomplex assays revealed that the JNK1 activity was strongly enhanced in both amygdala and hippocampus. Our findings demonstrate that rapid JNK activation and phosphorylation of c-Jun as stand-by transcription factor characterize the beginning of neuroplastic changes, e.g., following ECS, a classic treatment of mental disorders. The N-terminal phosphorylation is compartment specific and can habituate following repetitive stimulation suggesting that the differential activation of the JNK/c-Jun axis is part of the neuronal strategy to integrate transynaptic excitation." @default.
• W1990333514 created "2016-06-24" @default.
• W1990333514 creator A5013363726 @default.
• W1990333514 creator A5032012805 @default.
• W1990333514 creator A5036919122 @default.
• W1990333514 creator A5046329750 @default.
• W1990333514 creator A5054899787 @default.
• W1990333514 creator A5085766583 @default.
• W1990333514 date "1999-05-01" @default.
• W1990333514 modified "2023-10-16" @default.
• W1990333514 title "Repetitive electroconvulsive seizures induce activity of c-Jun N-terminal kinase and compartment-specific desensitization of c-Jun phosphorylation in the rat brain" @default.
• W1990333514 cites W1530284699 @default.
• W1990333514 cites W1549081254 @default.
• W1990333514 cites W1911507086 @default.
• W1990333514 cites W1945304257 @default.
• W1990333514 cites W1967746478 @default.
• W1990333514 cites W1968017447 @default.
• W1990333514 cites W1972145919 @default.
• W1990333514 cites W1972603245 @default.
• W1990333514 cites W1976385326 @default.
• W1990333514 cites W1988393864 @default.
• W1990333514 cites W1991647719 @default.
• W1990333514 cites W1994100377 @default.
• W1990333514 cites W1997038860 @default.
• W1990333514 cites W1997702529 @default.
• W1990333514 cites W1999695546 @default.
• W1990333514 cites W2000826578 @default.
• W1990333514 cites W2008106418 @default.
• W1990333514 cites W2017244291 @default.
• W1990333514 cites W2022564992 @default.
• W1990333514 cites W2042801834 @default.
• W1990333514 cites W2047604959 @default.
• W1990333514 cites W2052140698 @default.
• W1990333514 cites W2062730636 @default.
• W1990333514 cites W2065477683 @default.
• W1990333514 cites W2077664665 @default.
• W1990333514 cites W2077880395 @default.
• W1990333514 cites W2078971777 @default.
• W1990333514 cites W2080633303 @default.
• W1990333514 cites W2094068530 @default.
• W1990333514 cites W2139488506 @default.
• W1990333514 cites W2143532600 @default.
• W1990333514 cites W2154735464 @default.
• W1990333514 cites W2159872853 @default.
• W1990333514 cites W4229900040 @default.
• W1990333514 cites W4232513105 @default.
• W1990333514 doi "https://doi.org/10.1016/s0169-328x(99)00069-8" @default.
• W1990333514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10320787" @default.
• W1990333514 hasPublicationYear "1999" @default.
• W1990333514 type Work @default.
• W1990333514 sameAs 1990333514 @default.
• W1990333514 citedByCount "28" @default.
• W1990333514 countsByYear W19903335142012 @default.
• W1990333514 countsByYear W19903335142022 @default.
• W1990333514 crossrefType "journal-article" @default.
• W1990333514 hasAuthorship W1990333514A5013363726 @default.
• W1990333514 hasAuthorship W1990333514A5032012805 @default.
• W1990333514 hasAuthorship W1990333514A5036919122 @default.
• W1990333514 hasAuthorship W1990333514A5046329750 @default.
• W1990333514 hasAuthorship W1990333514A5054899787 @default.
• W1990333514 hasAuthorship W1990333514A5085766583 @default.
• W1990333514 hasConcept C104317684 @default.
• W1990333514 hasConcept C11960822 @default.
• W1990333514 hasConcept C126322002 @default.
• W1990333514 hasConcept C134018914 @default.
• W1990333514 hasConcept C150194340 @default.
• W1990333514 hasConcept C169760540 @default.
• W1990333514 hasConcept C184235292 @default.
• W1990333514 hasConcept C24998067 @default.
• W1990333514 hasConcept C2779087070 @default.
• W1990333514 hasConcept C2779555244 @default.
• W1990333514 hasConcept C2780382662 @default.
• W1990333514 hasConcept C2781041448 @default.
• W1990333514 hasConcept C2781161787 @default.
• W1990333514 hasConcept C55493867 @default.
• W1990333514 hasConcept C71924100 @default.
• W1990333514 hasConcept C74254510 @default.
• W1990333514 hasConcept C86339819 @default.
• W1990333514 hasConcept C86803240 @default.
• W1990333514 hasConcept C95444343 @default.
• W1990333514 hasConceptScore W1990333514C104317684 @default.
• W1990333514 hasConceptScore W1990333514C11960822 @default.
• W1990333514 hasConceptScore W1990333514C126322002 @default.
• W1990333514 hasConceptScore W1990333514C134018914 @default.
• W1990333514 hasConceptScore W1990333514C150194340 @default.
• W1990333514 hasConceptScore W1990333514C169760540 @default.
• W1990333514 hasConceptScore W1990333514C184235292 @default.
• W1990333514 hasConceptScore W1990333514C24998067 @default.
• W1990333514 hasConceptScore W1990333514C2779087070 @default.
• W1990333514 hasConceptScore W1990333514C2779555244 @default.
• W1990333514 hasConceptScore W1990333514C2780382662 @default.
• W1990333514 hasConceptScore W1990333514C2781041448 @default.
• W1990333514 hasConceptScore W1990333514C2781161787 @default.
• W1990333514 hasConceptScore W1990333514C55493867 @default.
• W1990333514 hasConceptScore W1990333514C71924100 @default.
• W1990333514 hasConceptScore W1990333514C74254510 @default.
• W1990333514 hasConceptScore W1990333514C86339819 @default.
• W1990333514 hasConceptScore W1990333514C86803240 @default.

• next