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- W1990333710 abstract "A non-protein chromophore(s), λmax 350 nm, was extracted by methanol from auromomycin. The methanol extracts of auromomycin and neocarzinostatin blocked growth of lymphoblastoma L5178Y cells. The degree of inhibition was similar to that by the original drugs. PM2 DNA was cleaved by auromomycin chromophore in the absence of reducing agents, whereas neocarzinostatin chromophore required 10 mM 2-mercaptoethanol for DNA strand scission. The DNA-cutting activities of the chromophores were slightly weaker than those of the native antibiotics. The protein fractions, left after methanol extraction, showed little activity on cell growth and isolated DNA. The results suggest that the chromophore moiety plays a predominant role in the inhibition of cell growth and cleavage of DNA." @default.
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- W1990333710 date "1980-05-01" @default.
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- W1990333710 title "Biological activities of non-protein chromophores of antitumor protein antibiotics: Auromomycin and neocarzinostatin" @default.
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- W1990333710 doi "https://doi.org/10.1016/s0006-291x(80)80214-2" @default.
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