FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990334559> ?p ?o ?g. }

• W1990334559 endingPage "129" @default.
• W1990334559 startingPage "118" @default.
• W1990334559 abstract "Abstract We have reported previously that apigenin, a naturally occurring nonmutagenic flavonoid, increased wild‐type p53 protein expression in the mouse keratinocyte 308 cell line by a mechanism involving p53 protein stabilization. Here we further demonstrated that the increase in p53 protein level induced by apigenin treatment of 308 keratinoyctes was not the result of enhanced transcription, mRNA stabilization or cytoplasmic export of p53 mRNA. Instead, biosynthetic labeling showed that apigenin increased nascent p53 protein synthesis by enhancing p53 translation. The AU‐rich element (ARE) within the 3′‐untranslated region (UTR) of p53 mRNA was found to be responsible for apigenin's ability to increase p53 translation, as demonstrated in studies wherein the 3′‐UTR of p53 mRNA containing the ARE was fused downstream of a luciferase reporter gene. Furthermore, apigenin treatment increased the level of association of the RNA binding protein HuR with endogenous p53 mRNA. Apigenin treatment also augmented HuR translocation into the cytoplasm. Overexpression of HuR enhanced apigenin‐induced p53 protein expression in 308 keratinocytes, whereas siRNA‐mediated HuR reduction suppressed apigenin‐induced p53 protein expression and de novo translation of p53. Moreover, apigenin treatment of cells induced p16 protein expression, which in turn was correlated with cytoplasmic localization of HuR induced by apigenin. Overall, these findings indicate that, in addition to modulating p53 protein stability, one of the mechanisms by which apigenin induces p53 protein expression is enhancement of translation through the RNA binding protein HuR. © 2008 Wiley‐Liss, Inc." @default.
• W1990334559 created "2016-06-24" @default.
• W1990334559 creator A5033888217 @default.
• W1990334559 creator A5070414768 @default.
• W1990334559 date "2008-08-04" @default.
• W1990334559 modified "2023-10-15" @default.
• W1990334559 title "Enhancement of p53 expression in keratinocytes by the bioflavonoid apigenin is associated with RNA-binding protein HuR" @default.
• W1990334559 cites W1606671377 @default.
• W1990334559 cites W1965314708 @default.
• W1990334559 cites W1968220278 @default.
• W1990334559 cites W1969077609 @default.
• W1990334559 cites W1973480874 @default.
• W1990334559 cites W1982925662 @default.
• W1990334559 cites W1989804578 @default.
• W1990334559 cites W1993170641 @default.
• W1990334559 cites W1995567920 @default.
• W1990334559 cites W2011172287 @default.
• W1990334559 cites W2015322909 @default.
• W1990334559 cites W2022162825 @default.
• W1990334559 cites W2023360526 @default.
• W1990334559 cites W2025296756 @default.
• W1990334559 cites W2026778985 @default.
• W1990334559 cites W2038019327 @default.
• W1990334559 cites W2051297868 @default.
• W1990334559 cites W2056723619 @default.
• W1990334559 cites W2058691182 @default.
• W1990334559 cites W2063669247 @default.
• W1990334559 cites W2071864203 @default.
• W1990334559 cites W2076232466 @default.
• W1990334559 cites W2091890751 @default.
• W1990334559 cites W2098671913 @default.
• W1990334559 cites W2100649307 @default.
• W1990334559 cites W2104398672 @default.
• W1990334559 cites W2110237197 @default.
• W1990334559 cites W2121140284 @default.
• W1990334559 cites W2145619015 @default.
• W1990334559 cites W2147471897 @default.
• W1990334559 cites W2316563275 @default.
• W1990334559 cites W2323207538 @default.
• W1990334559 doi "https://doi.org/10.1002/mc.20460" @default.
• W1990334559 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2631086" @default.
• W1990334559 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18680106" @default.
• W1990334559 hasPublicationYear "2008" @default.
• W1990334559 type Work @default.
• W1990334559 sameAs 1990334559 @default.
• W1990334559 citedByCount "24" @default.
• W1990334559 countsByYear W19903345592012 @default.
• W1990334559 countsByYear W19903345592013 @default.
• W1990334559 countsByYear W19903345592014 @default.
• W1990334559 countsByYear W19903345592015 @default.
• W1990334559 countsByYear W19903345592016 @default.
• W1990334559 countsByYear W19903345592017 @default.
• W1990334559 countsByYear W19903345592018 @default.
• W1990334559 countsByYear W19903345592019 @default.
• W1990334559 countsByYear W19903345592021 @default.
• W1990334559 countsByYear W19903345592022 @default.
• W1990334559 countsByYear W19903345592023 @default.
• W1990334559 crossrefType "journal-article" @default.
• W1990334559 hasAuthorship W1990334559A5033888217 @default.
• W1990334559 hasAuthorship W1990334559A5070414768 @default.
• W1990334559 hasBestOaLocation W19903345592 @default.
• W1990334559 hasConcept C104317684 @default.
• W1990334559 hasConcept C105580179 @default.
• W1990334559 hasConcept C138885662 @default.
• W1990334559 hasConcept C149364088 @default.
• W1990334559 hasConcept C150194340 @default.
• W1990334559 hasConcept C153911025 @default.
• W1990334559 hasConcept C179926584 @default.
• W1990334559 hasConcept C190062978 @default.
• W1990334559 hasConcept C2778004101 @default.
• W1990334559 hasConcept C2778609962 @default.
• W1990334559 hasConcept C2779054382 @default.
• W1990334559 hasConcept C3675279 @default.
• W1990334559 hasConcept C41282012 @default.
• W1990334559 hasConcept C41895202 @default.
• W1990334559 hasConcept C55493867 @default.
• W1990334559 hasConcept C67705224 @default.
• W1990334559 hasConcept C86803240 @default.
• W1990334559 hasConcept C89604277 @default.
• W1990334559 hasConcept C95444343 @default.
• W1990334559 hasConceptScore W1990334559C104317684 @default.
• W1990334559 hasConceptScore W1990334559C105580179 @default.
• W1990334559 hasConceptScore W1990334559C138885662 @default.
• W1990334559 hasConceptScore W1990334559C149364088 @default.
• W1990334559 hasConceptScore W1990334559C150194340 @default.
• W1990334559 hasConceptScore W1990334559C153911025 @default.
• W1990334559 hasConceptScore W1990334559C179926584 @default.
• W1990334559 hasConceptScore W1990334559C190062978 @default.
• W1990334559 hasConceptScore W1990334559C2778004101 @default.
• W1990334559 hasConceptScore W1990334559C2778609962 @default.
• W1990334559 hasConceptScore W1990334559C2779054382 @default.
• W1990334559 hasConceptScore W1990334559C3675279 @default.
• W1990334559 hasConceptScore W1990334559C41282012 @default.
• W1990334559 hasConceptScore W1990334559C41895202 @default.
• W1990334559 hasConceptScore W1990334559C55493867 @default.
• W1990334559 hasConceptScore W1990334559C67705224 @default.
• W1990334559 hasConceptScore W1990334559C86803240 @default.
• W1990334559 hasConceptScore W1990334559C89604277 @default.

• next