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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990335933> ?p ?o ?g. }

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• W1990335933 startingPage "1077" @default.
• W1990335933 abstract "We have developed a purified system that supports mismatch-dependent 5'-->3' excision. In the presence of RPA, ATP, and a mismatch, MutSalpha activates 5'-->3' excision by EXOI, and excision terminates after removal of the mispair. MutSalpha confers high processivity on EXOI, and termination is due to RPA-dependent displacement of this processive complex from the helix and a weak ability of EXOI to reload at the RPA-bound gap in the product, as well as MutSalpha- and MutLalpha-dependent suppression of EXOI activity in the absence of a mismatch cofactor. As observed in the purified system, excision directed by a 5' strand break in HeLa nuclear extract can proceed in the absence of MutLalpha or PCNA, although 3' excision in the extract system requires both proteins." @default.
• W1990335933 created "2016-06-24" @default.
• W1990335933 creator A5024370857 @default.
• W1990335933 creator A5026876597 @default.
• W1990335933 date "2003-11-01" @default.
• W1990335933 modified "2023-09-27" @default.
• W1990335933 title "Mechanism of 5′-Directed Excision in Human Mismatch Repair" @default.
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• W1990335933 doi "https://doi.org/10.1016/s1097-2765(03)00428-3" @default.
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