FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990339925> ?p ?o ?g. }

• W1990339925 endingPage "71" @default.
• W1990339925 startingPage "63" @default.
• W1990339925 abstract "Background. Reperfusion injury contributes to early organ malfunction after transplantation. The aim of this study was to characterize the ischemia-reperfusion injury after pancreas transplantation and to evaluate the effect of monoclonal antibody therapy against ICAM-1. Methods. Twenty-five heterotopic pancreas transplantations were performed in syngenic rats in a no-touch technique. Microcirculation and leukocyte-endothelial interaction in the grafts were evaluated by intravital microscopy at 1 hour (I), 6 hours (II), 12 hours (III), and 24 hours (IV) after reperfusion, and 12 hours after reperfusion (V) in the therapeutic group. In (V) antibodies against ICAM-1 were applied as bolus at reperfusion and continuously for 6 hours. Next to intravital microscopy, histologic scores, myeloperoxidase levels, and ICAM-1 expression were determined. Results. Microcirculation was significantly reduced in capillaries and postcapillary venules in the time course after reperfusion (capillary: 0.96 ± 0.08 mm/s [I] to 0.45 ± 0.07 mm/s [IV] [P <.01]) and was improved significantly by therapy with ICAM-1 antibodies (0.98 ± 0.06 mm/s, (P <.01). Leukocyte-endothelial interaction significantly increased 6 hours after reperfusion (II) (P <.01). These changes were paralleled by an increased endothelial expression of ICAM-1 in immunohistochemistry. Histologic evaluation showed increased inflammation at 12 hours after reperfusion (P <.01), which could be diminished by the administration of ICAM-1 antibodies (P <.05). Conclusion. Increased endothelial expression of ICAM-1 after pancreas transplantation is positively correlated with microcirculatory impairment. Important steps of pancreatic inflammation take place approximately 6 hours after reperfusion. Prophylactic application of monoclonal antibodies against ICAM-1 reduces reperfusion injury and successfully prevents the occurrence of graft pancreatitis. (Surgery 2003;134:63-71.)" @default.
• W1990339925 created "2016-06-24" @default.
• W1990339925 creator A5001389547 @default.
• W1990339925 creator A5005093437 @default.
• W1990339925 creator A5058360849 @default.
• W1990339925 creator A5067125554 @default.
• W1990339925 creator A5091639267 @default.
• W1990339925 date "2003-07-01" @default.
• W1990339925 modified "2023-10-18" @default.
• W1990339925 title "Characterization of ischemia/reperfusion injury after pancreas transplantation and reduction by application of monoclonal antibodies against ICAM-1 in the rat" @default.
• W1990339925 cites W1007804022 @default.
• W1990339925 cites W1970747862 @default.
• W1990339925 cites W1976131367 @default.
• W1990339925 cites W1982434107 @default.
• W1990339925 cites W1988788844 @default.
• W1990339925 cites W1989506871 @default.
• W1990339925 cites W1992041806 @default.
• W1990339925 cites W2002471385 @default.
• W1990339925 cites W2013685525 @default.
• W1990339925 cites W2021912241 @default.
• W1990339925 cites W2028428597 @default.
• W1990339925 cites W2028965877 @default.
• W1990339925 cites W2034097392 @default.
• W1990339925 cites W2038535348 @default.
• W1990339925 cites W2041432242 @default.
• W1990339925 cites W2046664293 @default.
• W1990339925 cites W2051960692 @default.
• W1990339925 cites W2059930904 @default.
• W1990339925 cites W2063513460 @default.
• W1990339925 cites W2066277926 @default.
• W1990339925 cites W2069250255 @default.
• W1990339925 cites W2071793636 @default.
• W1990339925 cites W2076197577 @default.
• W1990339925 cites W2094780760 @default.
• W1990339925 cites W2122980035 @default.
• W1990339925 cites W2129890973 @default.
• W1990339925 cites W2139427334 @default.
• W1990339925 cites W2149744820 @default.
• W1990339925 cites W2155516654 @default.
• W1990339925 cites W2396318980 @default.
• W1990339925 cites W2420038553 @default.
• W1990339925 cites W4214589643 @default.
• W1990339925 cites W4251694451 @default.
• W1990339925 cites W4293247451 @default.
• W1990339925 cites W4379136709 @default.
• W1990339925 doi "https://doi.org/10.1067/msy.2003.187" @default.
• W1990339925 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12874584" @default.
• W1990339925 hasPublicationYear "2003" @default.
• W1990339925 type Work @default.
• W1990339925 sameAs 1990339925 @default.
• W1990339925 citedByCount "16" @default.
• W1990339925 countsByYear W19903399252012 @default.
• W1990339925 countsByYear W19903399252013 @default.
• W1990339925 countsByYear W19903399252014 @default.
• W1990339925 countsByYear W19903399252021 @default.
• W1990339925 crossrefType "journal-article" @default.
• W1990339925 hasAuthorship W1990339925A5001389547 @default.
• W1990339925 hasAuthorship W1990339925A5005093437 @default.
• W1990339925 hasAuthorship W1990339925A5058360849 @default.
• W1990339925 hasAuthorship W1990339925A5067125554 @default.
• W1990339925 hasAuthorship W1990339925A5091639267 @default.
• W1990339925 hasConcept C126322002 @default.
• W1990339925 hasConcept C12722491 @default.
• W1990339925 hasConcept C142724271 @default.
• W1990339925 hasConcept C159654299 @default.
• W1990339925 hasConcept C16224149 @default.
• W1990339925 hasConcept C185946421 @default.
• W1990339925 hasConcept C203014093 @default.
• W1990339925 hasConcept C203565725 @default.
• W1990339925 hasConcept C204232928 @default.
• W1990339925 hasConcept C2776914184 @default.
• W1990339925 hasConcept C2778064082 @default.
• W1990339925 hasConcept C2778764654 @default.
• W1990339925 hasConcept C2780114680 @default.
• W1990339925 hasConcept C2780303639 @default.
• W1990339925 hasConcept C2859252 @default.
• W1990339925 hasConcept C2911091166 @default.
• W1990339925 hasConcept C541997718 @default.
• W1990339925 hasConcept C542903549 @default.
• W1990339925 hasConcept C71924100 @default.
• W1990339925 hasConceptScore W1990339925C126322002 @default.
• W1990339925 hasConceptScore W1990339925C12722491 @default.
• W1990339925 hasConceptScore W1990339925C142724271 @default.
• W1990339925 hasConceptScore W1990339925C159654299 @default.
• W1990339925 hasConceptScore W1990339925C16224149 @default.
• W1990339925 hasConceptScore W1990339925C185946421 @default.
• W1990339925 hasConceptScore W1990339925C203014093 @default.
• W1990339925 hasConceptScore W1990339925C203565725 @default.
• W1990339925 hasConceptScore W1990339925C204232928 @default.
• W1990339925 hasConceptScore W1990339925C2776914184 @default.
• W1990339925 hasConceptScore W1990339925C2778064082 @default.
• W1990339925 hasConceptScore W1990339925C2778764654 @default.
• W1990339925 hasConceptScore W1990339925C2780114680 @default.
• W1990339925 hasConceptScore W1990339925C2780303639 @default.
• W1990339925 hasConceptScore W1990339925C2859252 @default.
• W1990339925 hasConceptScore W1990339925C2911091166 @default.
• W1990339925 hasConceptScore W1990339925C541997718 @default.
• W1990339925 hasConceptScore W1990339925C542903549 @default.

• next