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- W1990346043 abstract "The 26S proteasome mediates ubiquitin-dependent proteolysis in eukaryotic cells. A number of studies including very recent ones have revealed that assembly of its 20S catalytic core particle is an ordered process that involves several conserved proteasome assembly chaperones (PACs). Two heterodimeric chaperones, PAC1-PAC2 and PAC3-PAC4, promote the assembly of rings composed of seven alpha subunits. Subsequently, beta subunits join to form half-proteasome precursor complexes containing all but one of the 14 subunits. These complexes lack the beta7 subunit but contain UMP1, another assembly chaperone, and in yeast, at least to some degree, the activator protein Blm10. Dimerization of two such complexes is triggered by incorporation of beta7, whose C-terminal extension reaches out into the other half to stabilize the newly formed 20S particle. The process is completed by the maturation of active sites and subsequent degradation of UMP1 and PAC1-PAC2." @default.
- W1990346043 created "2016-06-24" @default.
- W1990346043 creator A5050952876 @default.
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- W1990346043 date "2008-09-01" @default.
- W1990346043 modified "2023-09-26" @default.
- W1990346043 title "PACemakers of Proteasome Core Particle Assembly" @default.
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- W1990346043 doi "https://doi.org/10.1016/j.str.2008.07.001" @default.
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