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- W1990347373 abstract "Regulatory T (Treg) cells require the cytokine IL-2 for their development. Bishop and colleagues show that the adaptor molecule TRAF3 reduces IL-2 receptor signaling and thereby restrains Treg cell development. The number of Foxp3+ regulatory T cells (Treg cells) must be tightly controlled for efficient suppression of autoimmunity with no impairment of normal immune responses. Here we found that the adaptor TRAF3 was intrinsically required for restraining the lineage determination of thymic Treg cells. T cell–specific deficiency in TRAF3 resulted in a two- to threefold greater frequency of Treg cells, due to the more efficient transition of precursors of Treg cells into Foxp3+ Treg cells. TRAF3 dampened interleukin 2 (IL-2) signaling by facilitating recruitment of the tyrosine phosphatase TCPTP to the IL-2 receptor complex, which resulted in dephosphorylation of the signaling molecules Jak1 and Jak3 and negative regulation of signaling via Jak and the transcription factor STAT5. Our results identify a role for TRAF3 as an important negative regulator of signaling via the IL-2 receptor that affects the development of Treg cells." @default.
- W1990347373 created "2016-06-24" @default.
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- W1990347373 date "2014-07-20" @default.
- W1990347373 modified "2023-10-01" @default.
- W1990347373 title "The adaptor TRAF3 restrains the lineage determination of thymic regulatory T cells by modulating signaling via the receptor for IL-2" @default.
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- W1990347373 doi "https://doi.org/10.1038/ni.2944" @default.
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