Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990351639> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1990351639 endingPage "265" @default.
- W1990351639 startingPage "261" @default.
- W1990351639 abstract "During embryonic development, morphogenetic gradients can specify the formation of gene expression territories. Here, we explore possible commonalities between pattern formation in the Drosophila blastoderm and murine pituitary. Shared principles include the need for positive feedback involving fate-determining genes to maintain a differentiated state, and the existence of intra- or extracellular inhibitory signals that improve spatial resolution of neighboring territories. The precision of spatial segregation is, however, limited by stochastic gene expression. Variability in gene expression at territory boundaries might give rise to a poorly differentiated pool of cells, which could harbor stem-like properties. The ideas outlined here deserve further theoretical and experimental exploration. During embryonic development, morphogenetic gradients can specify the formation of gene expression territories. Here, we explore possible commonalities between pattern formation in the Drosophila blastoderm and murine pituitary. Shared principles include the need for positive feedback involving fate-determining genes to maintain a differentiated state, and the existence of intra- or extracellular inhibitory signals that improve spatial resolution of neighboring territories. The precision of spatial segregation is, however, limited by stochastic gene expression. Variability in gene expression at territory boundaries might give rise to a poorly differentiated pool of cells, which could harbor stem-like properties. The ideas outlined here deserve further theoretical and experimental exploration." @default.
- W1990351639 created "2016-06-24" @default.
- W1990351639 creator A5025275078 @default.
- W1990351639 creator A5037392750 @default.
- W1990351639 date "2007-09-01" @default.
- W1990351639 modified "2023-09-30" @default.
- W1990351639 title "Commonalities in fly embryogenesis and mammalian pituitary patterning" @default.
- W1990351639 cites W1751597108 @default.
- W1990351639 cites W1979040385 @default.
- W1990351639 cites W1988017462 @default.
- W1990351639 cites W1999189478 @default.
- W1990351639 cites W2013128939 @default.
- W1990351639 cites W2016546231 @default.
- W1990351639 cites W2030528185 @default.
- W1990351639 cites W2040335200 @default.
- W1990351639 cites W2041603328 @default.
- W1990351639 cites W2046490342 @default.
- W1990351639 cites W2048312155 @default.
- W1990351639 cites W2048640907 @default.
- W1990351639 cites W2054575205 @default.
- W1990351639 cites W2056623845 @default.
- W1990351639 cites W2061883669 @default.
- W1990351639 cites W2062502773 @default.
- W1990351639 cites W2064557280 @default.
- W1990351639 cites W2079385876 @default.
- W1990351639 cites W2083022446 @default.
- W1990351639 cites W2088286107 @default.
- W1990351639 cites W2098069596 @default.
- W1990351639 cites W2104407210 @default.
- W1990351639 cites W2129829180 @default.
- W1990351639 cites W2143187272 @default.
- W1990351639 cites W2149994559 @default.
- W1990351639 cites W2152149172 @default.
- W1990351639 cites W2153904514 @default.
- W1990351639 cites W2160314966 @default.
- W1990351639 cites W2163808584 @default.
- W1990351639 cites W2166012954 @default.
- W1990351639 cites W2184453560 @default.
- W1990351639 doi "https://doi.org/10.1016/j.tem.2007.08.002" @default.
- W1990351639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17693094" @default.
- W1990351639 hasPublicationYear "2007" @default.
- W1990351639 type Work @default.
- W1990351639 sameAs 1990351639 @default.
- W1990351639 citedByCount "4" @default.
- W1990351639 countsByYear W19903516392012 @default.
- W1990351639 crossrefType "journal-article" @default.
- W1990351639 hasAuthorship W1990351639A5025275078 @default.
- W1990351639 hasAuthorship W1990351639A5037392750 @default.
- W1990351639 hasConcept C104317684 @default.
- W1990351639 hasConcept C145103041 @default.
- W1990351639 hasConcept C150194340 @default.
- W1990351639 hasConcept C163952510 @default.
- W1990351639 hasConcept C165864922 @default.
- W1990351639 hasConcept C183074962 @default.
- W1990351639 hasConcept C196843134 @default.
- W1990351639 hasConcept C54355233 @default.
- W1990351639 hasConcept C86339819 @default.
- W1990351639 hasConcept C86803240 @default.
- W1990351639 hasConcept C87073359 @default.
- W1990351639 hasConcept C95444343 @default.
- W1990351639 hasConcept C98535976 @default.
- W1990351639 hasConceptScore W1990351639C104317684 @default.
- W1990351639 hasConceptScore W1990351639C145103041 @default.
- W1990351639 hasConceptScore W1990351639C150194340 @default.
- W1990351639 hasConceptScore W1990351639C163952510 @default.
- W1990351639 hasConceptScore W1990351639C165864922 @default.
- W1990351639 hasConceptScore W1990351639C183074962 @default.
- W1990351639 hasConceptScore W1990351639C196843134 @default.
- W1990351639 hasConceptScore W1990351639C54355233 @default.
- W1990351639 hasConceptScore W1990351639C86339819 @default.
- W1990351639 hasConceptScore W1990351639C86803240 @default.
- W1990351639 hasConceptScore W1990351639C87073359 @default.
- W1990351639 hasConceptScore W1990351639C95444343 @default.
- W1990351639 hasConceptScore W1990351639C98535976 @default.
- W1990351639 hasIssue "7" @default.
- W1990351639 hasLocation W19903516391 @default.
- W1990351639 hasLocation W19903516392 @default.
- W1990351639 hasOpenAccess W1990351639 @default.
- W1990351639 hasPrimaryLocation W19903516391 @default.
- W1990351639 hasRelatedWork W1984414065 @default.
- W1990351639 hasRelatedWork W2072954505 @default.
- W1990351639 hasRelatedWork W2078823221 @default.
- W1990351639 hasRelatedWork W2151285117 @default.
- W1990351639 hasRelatedWork W2169340257 @default.
- W1990351639 hasRelatedWork W2182494171 @default.
- W1990351639 hasRelatedWork W2392240462 @default.
- W1990351639 hasRelatedWork W3196731354 @default.
- W1990351639 hasRelatedWork W4240122745 @default.
- W1990351639 hasRelatedWork W2346832345 @default.
- W1990351639 hasVolume "18" @default.
- W1990351639 isParatext "false" @default.
- W1990351639 isRetracted "false" @default.
- W1990351639 magId "1990351639" @default.
- W1990351639 workType "article" @default.