Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990353742> ?p ?o ?g. }
- W1990353742 endingPage "545" @default.
- W1990353742 startingPage "526" @default.
- W1990353742 abstract "Wnt signaling pathway plays a critical role in numerous cellular processes, including tumor initiation, proliferation, invasion/infiltration, metastasis formation and resistance to chemotherapy. In a drug discovery project aimed at the identification of inhibitors of the canonical Wnt pathway, we selected a series of quinazoline 2,4-diones as starting point for the therapeutic treatment of glioblastoma multiforme. Despite of poor physico-chemical properties of hit compound 1, our medicinal chemistry effort allowed the discovery and characterization of lead compound 33 (SEN461), with improved ADME profile, good bioavailability and active in vitro and in vivo in glioblastoma, gastric and sarcoma tumors." @default.
- W1990353742 created "2016-06-24" @default.
- W1990353742 creator A5003336792 @default.
- W1990353742 creator A5007718272 @default.
- W1990353742 creator A5009359323 @default.
- W1990353742 creator A5017717228 @default.
- W1990353742 creator A5018392096 @default.
- W1990353742 creator A5028944416 @default.
- W1990353742 creator A5030409570 @default.
- W1990353742 creator A5034583993 @default.
- W1990353742 creator A5036057132 @default.
- W1990353742 creator A5038135757 @default.
- W1990353742 creator A5042621293 @default.
- W1990353742 creator A5044992338 @default.
- W1990353742 creator A5050473898 @default.
- W1990353742 creator A5059247059 @default.
- W1990353742 creator A5070547304 @default.
- W1990353742 creator A5079732660 @default.
- W1990353742 creator A5083804280 @default.
- W1990353742 creator A5087652032 @default.
- W1990353742 creator A5090320853 @default.
- W1990353742 date "2015-05-01" @default.
- W1990353742 modified "2023-09-25" @default.
- W1990353742 title "Structure–activity relationship and properties optimization of a series of Quinazoline-2,4-diones as inhibitors of the canonical Wnt pathway" @default.
- W1990353742 cites W1612964469 @default.
- W1990353742 cites W1965156941 @default.
- W1990353742 cites W1968064237 @default.
- W1990353742 cites W1975361178 @default.
- W1990353742 cites W1989041481 @default.
- W1990353742 cites W1990923693 @default.
- W1990353742 cites W1993347240 @default.
- W1990353742 cites W1994029539 @default.
- W1990353742 cites W1998892616 @default.
- W1990353742 cites W2008657782 @default.
- W1990353742 cites W2013891209 @default.
- W1990353742 cites W2029250802 @default.
- W1990353742 cites W2030621485 @default.
- W1990353742 cites W2034373020 @default.
- W1990353742 cites W2035621887 @default.
- W1990353742 cites W2035809306 @default.
- W1990353742 cites W2042173734 @default.
- W1990353742 cites W2045828622 @default.
- W1990353742 cites W2057257265 @default.
- W1990353742 cites W2057995674 @default.
- W1990353742 cites W2058043554 @default.
- W1990353742 cites W2065666905 @default.
- W1990353742 cites W2080713919 @default.
- W1990353742 cites W2085703367 @default.
- W1990353742 cites W2096175781 @default.
- W1990353742 cites W2097132248 @default.
- W1990353742 cites W2101889783 @default.
- W1990353742 cites W2105240743 @default.
- W1990353742 cites W2115966942 @default.
- W1990353742 cites W2119780609 @default.
- W1990353742 cites W2125916283 @default.
- W1990353742 cites W2133505501 @default.
- W1990353742 cites W2141231260 @default.
- W1990353742 cites W2144311146 @default.
- W1990353742 cites W2147025907 @default.
- W1990353742 cites W2149987834 @default.
- W1990353742 cites W2154345686 @default.
- W1990353742 cites W2158021558 @default.
- W1990353742 cites W2159306692 @default.
- W1990353742 cites W2165061154 @default.
- W1990353742 cites W2165087323 @default.
- W1990353742 cites W2239090104 @default.
- W1990353742 cites W2318878569 @default.
- W1990353742 cites W2323290668 @default.
- W1990353742 cites W2035070138 @default.
- W1990353742 doi "https://doi.org/10.1016/j.ejmech.2015.03.055" @default.
- W1990353742 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25847770" @default.
- W1990353742 hasPublicationYear "2015" @default.
- W1990353742 type Work @default.
- W1990353742 sameAs 1990353742 @default.
- W1990353742 citedByCount "14" @default.
- W1990353742 countsByYear W19903537422015 @default.
- W1990353742 countsByYear W19903537422016 @default.
- W1990353742 countsByYear W19903537422017 @default.
- W1990353742 countsByYear W19903537422020 @default.
- W1990353742 countsByYear W19903537422021 @default.
- W1990353742 countsByYear W19903537422022 @default.
- W1990353742 countsByYear W19903537422023 @default.
- W1990353742 crossrefType "journal-article" @default.
- W1990353742 hasAuthorship W1990353742A5003336792 @default.
- W1990353742 hasAuthorship W1990353742A5007718272 @default.
- W1990353742 hasAuthorship W1990353742A5009359323 @default.
- W1990353742 hasAuthorship W1990353742A5017717228 @default.
- W1990353742 hasAuthorship W1990353742A5018392096 @default.
- W1990353742 hasAuthorship W1990353742A5028944416 @default.
- W1990353742 hasAuthorship W1990353742A5030409570 @default.
- W1990353742 hasAuthorship W1990353742A5034583993 @default.
- W1990353742 hasAuthorship W1990353742A5036057132 @default.
- W1990353742 hasAuthorship W1990353742A5038135757 @default.
- W1990353742 hasAuthorship W1990353742A5042621293 @default.
- W1990353742 hasAuthorship W1990353742A5044992338 @default.
- W1990353742 hasAuthorship W1990353742A5050473898 @default.
- W1990353742 hasAuthorship W1990353742A5059247059 @default.
- W1990353742 hasAuthorship W1990353742A5070547304 @default.