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- W1990354192 abstract "Cardiac failure due to iron overload remains the most common cause of death in patients with beta-thalassemia major. This study aimed to evaluate myocardial function in children with beta-thalassemia major using standard echocardiography technique and strain rate imaging.Conventional echocardiographic analysis, tissue velocity imaging, and strain/strain rate imaging of the left ventricle were evaluated in 48 children with beta-thalassemia major (19 girls, 29 boys; 8.39±4.05 years) and 22 healthy children (11 girls, 11 boys; 8±3.72 years).Conventional echocardiographic examinations revealed that beta-thalassemia patients had larger left ventricular end-systolic diameter, end-diastolic and end-systolic volume, left ventricular mass index, and mitral early/late diastolic flow velocity ratio (p<0.05). Strain and strain rate imaging study of the basal lateral wall of the left ventricle was higher in patients than in controls, at p=0.035 and p=0.008, respectively.We found that superior systolic strain and strain rate imaging of the left ventricle indicated the presence of regional systolic function in the left ventricular wall. We suggest that left ventricle volume and mass index parameters might be more sensitive than the other conventional and strain/strain rate imaging parameters during childhood. However, the adulthood strain and strain rate imaging values may be lower than controls, exceeding the critical level of iron overload.None declared.Amaç: Beta talasemi majörlü hastalarda demir yüklenmesine bağlı kalp yetmezliği en sık ölüm nedenidir. Bu çalışmada beta talasemi majörlü çocuklarda standart ekokardiyografi ve strain rate görüntüleme ile myokardiyal fonksiyonun değerlendirilmesi amaçlanmıştır. Gereç ve Yöntemler: Çalışmamızda rutin ekokardiyografik değerlendirme ile beraber sol ventrikülün doku velosite görüntülenmesi, strain/strain rate görüntülemesi beta talasemi majörlü 48 çocukta (19 kız, 29 erkek; 8.39±4.05 yıl) ve 22 sağlıklı çocukta (11 kız, 11 erkek; 8±3.72 yıl) ölçülmüştür. Bulgular: Rutin ekokardiyografik değerlendirmede beta talasemi majörlü hastalarda daha geniş sol ventrikül sistol sonu çap, diyastol ve sistol sonu hacmi olduğu, kitlesinin artmış olduğu ve mitral kapak erken/geç diyastolik akım oranının artmış olduğu görüldü (p<0.05). Sol ventrikül bazal lateral duvarı strain ve strain rate görüntülemesi değerleri hasta grubunda kontrole göre anlamlı yüksek değerdeydi (sırası ile p=0.035 ve p=0.008). Sonuç: Sol ventrikül superior strain ve strain rate görüntülemesinde sol ventrikül duvarının bölgesel sistolik fonksiyonunu koruduğunu bulduk. Çocukluk çağında sol ventrikül hacim ve kitle indeksi göstergelerinin diğer geleneksel ve strain/strain rate görüntüleme göstergelerine göre daha duyarlı olabileceğini düşünmekteyiz. Bununla beraber, erişkin döneminde demir yüklenmesinin kritik seviyeyi aşması ile strain ve strain rate görüntüleme değerleri kontrol olgularınınkinden daha düşük bulunabilir." @default.
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- W1990354192 date "2013-09-05" @default.
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- W1990354192 title "Detection of Left Ventricular Regional Function in Asymptomatic Children with beta-Thalassemia Major by Longitudinal Strain and Strain Rate Imaging" @default.
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- W1990354192 doi "https://doi.org/10.4274/tjh.2012.0065" @default.
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