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- W1990355918 abstract "—Cerebrovascular and cerebral metabolic responses to changes in arterial PCO2 were tested in young (4 month) and aged (24 month) Sprague-Dawley rats. Rats were anesthetized with 70% nitrous oxide and 30% oxygen, paralyzed with tubocurare and artificially ventilated. Cerebral blood flow (CBF) was measured with radioactive microspheres and cerebral oxygen metabolism (CMRO2 was analyzed from arterial and sagittal sinus oxygen content differences. CBF increased in both young and aged rats with increasing arterial PCO2. Aged rats had significantly depressed cerebrovascular reactivity to changes in CO2 compared to young rats (p<0.05). CMRO2 was not significantly different between young and aged rats and did not significantly change with changes in arterial PCO2." @default.
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- W1990355918 date "1982-06-01" @default.
- W1990355918 modified "2023-10-11" @default.
- W1990355918 title "Cerebrovascular and cerebral metabolic responses of aged rats to changes in arterial PCO2" @default.
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- W1990355918 doi "https://doi.org/10.1016/0197-4580(82)90010-0" @default.
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