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- W1990366821 abstract "The opioid system has been implicated in mood disorders as well as in the mechanism of action of antidepressants. Since the opioid component in venlafaxine (VLX) is still a matter of discussion, we investigated the role of opioid receptors in the antidepressant-like effect of VLX in the forced swimming test in mice. The non-selective opiate antagonist naloxone at high dose (2 mg/kg, s.c.) antagonized the effect of VLX. In contrast, β-funaltrexamine (40 mg/kg, s.c.), which preferentially blocks μ1/μ2 opioid receptors, naloxonazine (35 mg/kg, s.c.), a selective μ1 opioid antagonist, naltrindole (10 mg/kg, s.c.), a selective δ opioid antagonist, and Nor-binaltorphimine (10 mg/kg, s.c.), which selectively blocks κ-opioid receptors, were all ineffective. Thus, although apparently mediated by the opioid system, the behavioural effect of VLX does not involve specific opioid receptors." @default.
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- W1990366821 date "2004-06-01" @default.
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- W1990366821 title "Non-selective opioid receptor antagonism of the antidepressant-like effect of venlafaxine in the forced swimming test in mice" @default.
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- W1990366821 doi "https://doi.org/10.1016/j.neulet.2004.03.041" @default.
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