FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990367039> ?p ?o ?g. }

• W1990367039 endingPage "7877" @default.
• W1990367039 startingPage "7865" @default.
• W1990367039 abstract "The frequency and distribution of the rare dinucleotide CpG was examined in 15 mammalian genes. CpG is highly methylated at cytosine in mammalian DNA (1,2) and 5-methylcytosine (5mC) is thought to undergo a transition mutation via deamination to produce thymine (3). This would result in the accumulation of TpG and CpA and depletion of CpG during evolution (4). Consistent with this hypothesis, the gene sample of 26,541 dinucleotides contained CpG at 40% the frequency expected by base composition and the CpG transition products, TpG+CpA, were significantly elevated at 124% of expected random frequency. However, because CpG occurs at only 25% of expected random frequency in the genome, the sampled genes were considerably enriched in this dinucleotide. CpGs were asymmetrically distributed in sequences flanking the genes. 5'-flanking sequences were enriched in CpG at 135% of the frequency expected assuming a symmetrical distribution of all the CpGs in the sampled genes (p less than 0.01), while 3'-flanking regions were depleted in CpG at 40% of expected values (p less than 0.0001). This asymmetry may reflect the role of 5-methylcytosine in gene expression. In contrast the frequencies of GpC and GpT+ ApC did not differ significantly from that predicted by base composition and these dinucleotides were not asymmetrically distributed." @default.
• W1990367039 created "2016-06-24" @default.
• W1990367039 creator A5048109615 @default.
• W1990367039 creator A5083233960 @default.
• W1990367039 date "1982-01-01" @default.
• W1990367039 modified "2023-09-25" @default.
• W1990367039 title "Asymmetrical distribution of CpG in an ‘average’ mammalian gene" @default.
• W1990367039 cites W1557272981 @default.
• W1990367039 cites W1822019043 @default.
• W1990367039 cites W1964556049 @default.
• W1990367039 cites W1968266985 @default.
• W1990367039 cites W1972886942 @default.
• W1990367039 cites W1978968014 @default.
• W1990367039 cites W1980079031 @default.
• W1990367039 cites W1985202731 @default.
• W1990367039 cites W1986402189 @default.
• W1990367039 cites W1988218731 @default.
• W1990367039 cites W1988596667 @default.
• W1990367039 cites W1988819320 @default.
• W1990367039 cites W1990125516 @default.
• W1990367039 cites W1998517881 @default.
• W1990367039 cites W2001337273 @default.
• W1990367039 cites W2006050041 @default.
• W1990367039 cites W2010501569 @default.
• W1990367039 cites W2011182863 @default.
• W1990367039 cites W2013891685 @default.
• W1990367039 cites W2016197401 @default.
• W1990367039 cites W2016240281 @default.
• W1990367039 cites W2021889598 @default.
• W1990367039 cites W2022187295 @default.
• W1990367039 cites W2024457805 @default.
• W1990367039 cites W2027059027 @default.
• W1990367039 cites W2031526147 @default.
• W1990367039 cites W2034105248 @default.
• W1990367039 cites W2045402478 @default.
• W1990367039 cites W2050615089 @default.
• W1990367039 cites W2062043721 @default.
• W1990367039 cites W2067692728 @default.
• W1990367039 cites W2069526940 @default.
• W1990367039 cites W2088529832 @default.
• W1990367039 cites W2091602444 @default.
• W1990367039 cites W2092245630 @default.
• W1990367039 cites W2093908800 @default.
• W1990367039 cites W2115399760 @default.
• W1990367039 cites W2120033918 @default.
• W1990367039 cites W2167110107 @default.
• W1990367039 cites W2332949416 @default.
• W1990367039 doi "https://doi.org/10.1093/nar/10.23.7865" @default.
• W1990367039 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/327052" @default.
• W1990367039 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7155899" @default.
• W1990367039 hasPublicationYear "1982" @default.
• W1990367039 type Work @default.
• W1990367039 sameAs 1990367039 @default.
• W1990367039 citedByCount "133" @default.
• W1990367039 countsByYear W19903670392012 @default.
• W1990367039 countsByYear W19903670392013 @default.
• W1990367039 countsByYear W19903670392014 @default.
• W1990367039 countsByYear W19903670392015 @default.
• W1990367039 countsByYear W19903670392016 @default.
• W1990367039 countsByYear W19903670392018 @default.
• W1990367039 countsByYear W19903670392019 @default.
• W1990367039 countsByYear W19903670392020 @default.
• W1990367039 countsByYear W19903670392021 @default.
• W1990367039 countsByYear W19903670392022 @default.
• W1990367039 crossrefType "journal-article" @default.
• W1990367039 hasAuthorship W1990367039A5048109615 @default.
• W1990367039 hasAuthorship W1990367039A5083233960 @default.
• W1990367039 hasBestOaLocation W19903670392 @default.
• W1990367039 hasConcept C104317684 @default.
• W1990367039 hasConcept C140173407 @default.
• W1990367039 hasConcept C145782189 @default.
• W1990367039 hasConcept C150194340 @default.
• W1990367039 hasConcept C153911025 @default.
• W1990367039 hasConcept C181199279 @default.
• W1990367039 hasConcept C190727270 @default.
• W1990367039 hasConcept C194232998 @default.
• W1990367039 hasConcept C2775926025 @default.
• W1990367039 hasConcept C2776023528 @default.
• W1990367039 hasConcept C501734568 @default.
• W1990367039 hasConcept C54355233 @default.
• W1990367039 hasConcept C552990157 @default.
• W1990367039 hasConcept C55493867 @default.
• W1990367039 hasConcept C86803240 @default.
• W1990367039 hasConceptScore W1990367039C104317684 @default.
• W1990367039 hasConceptScore W1990367039C140173407 @default.
• W1990367039 hasConceptScore W1990367039C145782189 @default.
• W1990367039 hasConceptScore W1990367039C150194340 @default.
• W1990367039 hasConceptScore W1990367039C153911025 @default.
• W1990367039 hasConceptScore W1990367039C181199279 @default.
• W1990367039 hasConceptScore W1990367039C190727270 @default.
• W1990367039 hasConceptScore W1990367039C194232998 @default.
• W1990367039 hasConceptScore W1990367039C2775926025 @default.
• W1990367039 hasConceptScore W1990367039C2776023528 @default.
• W1990367039 hasConceptScore W1990367039C501734568 @default.
• W1990367039 hasConceptScore W1990367039C54355233 @default.
• W1990367039 hasConceptScore W1990367039C552990157 @default.
• W1990367039 hasConceptScore W1990367039C55493867 @default.
• W1990367039 hasConceptScore W1990367039C86803240 @default.

• next