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- W1990369339 abstract "Abstract The zinc ion coordination of vincristine was studied by polarography; the analogous calcium ion coordination process was studied potentiometrically by a calcium ion selective electrode. In both cases, complexes of 1:1 composition were formed. The formation constant of the calcium complex was found to be 1g K = 3.27 ± 0.1. On the basis of the substitution of zinc in its vincristine complex by calcium and magnesium ions respectively, the ratio of the corresponding stability constants could be estimated as KZn:KCa (and KZn:KMg) ∼ 105−3 × 104. The complex formation processes proved to be pH-independent in the pH range 3.4–5.5, indicating that the metal ions are coordinated by the unprotonated oxygen donor atoms of vincristine." @default.
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- W1990369339 date "1986-08-01" @default.
- W1990369339 modified "2023-10-17" @default.
- W1990369339 title "Calcium, magnesium and zinc ion coordination equilibria of vincristine" @default.
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- W1990369339 doi "https://doi.org/10.1016/s0020-1693(00)83288-0" @default.
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