FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990375907> ?p ?o ?g. }

• W1990375907 endingPage "121" @default.
• W1990375907 startingPage "112" @default.
• W1990375907 abstract "Dicationic diarylfurans and dicationic carbazoles are under development as therapeutic agents against opportunistic infections. While their ability to bind to the minor groove of DNA has been established, the complete mechanism of action has not. We demonstrate here that an effective diarylfuran, 2,5-bis[4-(N-isopropylguanyl)phenyl]furan, inhibits an endo/exonuclease activity present in Pneumocystis carinii, Cryptococcus neoformans, Candida albicans, and Saccharomyces cerevisiae. This activity was purified from the particulate fraction of P. carinii. The enzyme requires Mg++ or Mn++, and shows preferences for single-over double stranded DNA and for AT-rich over GC-rich domains. A panel of 12 dicationic diarylfurans and eight dicationic carbazoles, previously synthesized, were evaluated for inhibition of the purified nuclease and for efficacy against Pneumocystis pneumonia in rats. Among the diarylfurans, potency of nuclease inhibition, in vivo antimicrobial activity, and DNA binding strength were all strongly correlated (p < 0.001). These findings suggest that one target for antimicrobial action of the diarylfurans may be a nucleolytic or other event requiring unpairing of DNA strands. Dicationic carbazoles which were strong nuclease inhibitors all displayed anti-Pneumocystis activity in vivo, but there were also noninhibitory carbazoles with in vivo efficacy." @default.
• W1990375907 created "2016-06-24" @default.
• W1990375907 creator A5019942523 @default.
• W1990375907 creator A5045703187 @default.
• W1990375907 creator A5073492250 @default.
• W1990375907 creator A5078465271 @default.
• W1990375907 creator A5080123057 @default.
• W1990375907 date "1998-01-01" @default.
• W1990375907 modified "2023-10-10" @default.
• W1990375907 title "Identification and Characterization of an Endo/exonuclease in Pneumocystis carinii that is Inhibited by Dicationic Diarylfurans with Efficacy Against Pneumocystis Pneumonia" @default.
• W1990375907 cites W1495883658 @default.
• W1990375907 cites W1517624463 @default.
• W1990375907 cites W1531641239 @default.
• W1990375907 cites W1558516755 @default.
• W1990375907 cites W1909381174 @default.
• W1990375907 cites W1971015083 @default.
• W1990375907 cites W1975833163 @default.
• W1990375907 cites W1987626964 @default.
• W1990375907 cites W1991922943 @default.
• W1990375907 cites W2006304964 @default.
• W1990375907 cites W2008962877 @default.
• W1990375907 cites W2013353995 @default.
• W1990375907 cites W2014286993 @default.
• W1990375907 cites W2029013111 @default.
• W1990375907 cites W2033752481 @default.
• W1990375907 cites W2044455775 @default.
• W1990375907 cites W2051077075 @default.
• W1990375907 cites W2074635589 @default.
• W1990375907 cites W2081112736 @default.
• W1990375907 cites W2083981294 @default.
• W1990375907 cites W2100837269 @default.
• W1990375907 cites W2101108802 @default.
• W1990375907 cites W2128635872 @default.
• W1990375907 cites W2153575993 @default.
• W1990375907 cites W2157094125 @default.
• W1990375907 cites W2323336772 @default.
• W1990375907 cites W54353785 @default.
• W1990375907 doi "https://doi.org/10.1111/j.1550-7408.1998.tb05078.x" @default.
• W1990375907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9495040" @default.
• W1990375907 hasPublicationYear "1998" @default.
• W1990375907 type Work @default.
• W1990375907 sameAs 1990375907 @default.
• W1990375907 citedByCount "26" @default.
• W1990375907 countsByYear W19903759072012 @default.
• W1990375907 countsByYear W19903759072015 @default.
• W1990375907 crossrefType "journal-article" @default.
• W1990375907 hasAuthorship W1990375907A5019942523 @default.
• W1990375907 hasAuthorship W1990375907A5045703187 @default.
• W1990375907 hasAuthorship W1990375907A5073492250 @default.
• W1990375907 hasAuthorship W1990375907A5078465271 @default.
• W1990375907 hasAuthorship W1990375907A5080123057 @default.
• W1990375907 hasConcept C159047783 @default.
• W1990375907 hasConcept C207001950 @default.
• W1990375907 hasConcept C2756471 @default.
• W1990375907 hasConcept C2777271071 @default.
• W1990375907 hasConcept C2777501222 @default.
• W1990375907 hasConcept C2777559004 @default.
• W1990375907 hasConcept C2777893358 @default.
• W1990375907 hasConcept C2780917455 @default.
• W1990375907 hasConcept C2993443204 @default.
• W1990375907 hasConcept C3013748606 @default.
• W1990375907 hasConcept C54355233 @default.
• W1990375907 hasConcept C552990157 @default.
• W1990375907 hasConcept C55493867 @default.
• W1990375907 hasConcept C86803240 @default.
• W1990375907 hasConcept C89423630 @default.
• W1990375907 hasConceptScore W1990375907C159047783 @default.
• W1990375907 hasConceptScore W1990375907C207001950 @default.
• W1990375907 hasConceptScore W1990375907C2756471 @default.
• W1990375907 hasConceptScore W1990375907C2777271071 @default.
• W1990375907 hasConceptScore W1990375907C2777501222 @default.
• W1990375907 hasConceptScore W1990375907C2777559004 @default.
• W1990375907 hasConceptScore W1990375907C2777893358 @default.
• W1990375907 hasConceptScore W1990375907C2780917455 @default.
• W1990375907 hasConceptScore W1990375907C2993443204 @default.
• W1990375907 hasConceptScore W1990375907C3013748606 @default.
• W1990375907 hasConceptScore W1990375907C54355233 @default.
• W1990375907 hasConceptScore W1990375907C552990157 @default.
• W1990375907 hasConceptScore W1990375907C55493867 @default.
• W1990375907 hasConceptScore W1990375907C86803240 @default.
• W1990375907 hasConceptScore W1990375907C89423630 @default.
• W1990375907 hasIssue "1" @default.
• W1990375907 hasLocation W19903759071 @default.
• W1990375907 hasLocation W19903759072 @default.
• W1990375907 hasOpenAccess W1990375907 @default.
• W1990375907 hasPrimaryLocation W19903759071 @default.
• W1990375907 hasRelatedWork W1946022519 @default.
• W1990375907 hasRelatedWork W2001313812 @default.
• W1990375907 hasRelatedWork W2006727124 @default.
• W1990375907 hasRelatedWork W2032412493 @default.
• W1990375907 hasRelatedWork W2041517388 @default.
• W1990375907 hasRelatedWork W2056030955 @default.
• W1990375907 hasRelatedWork W2086103125 @default.
• W1990375907 hasRelatedWork W2092997021 @default.
• W1990375907 hasRelatedWork W2356279602 @default.
• W1990375907 hasRelatedWork W2951288028 @default.
• W1990375907 hasVolume "45" @default.
• W1990375907 isParatext "false" @default.

• next