FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990379370> ?p ?o ?g. }

• W1990379370 endingPage "612" @default.
• W1990379370 startingPage "595" @default.
• W1990379370 abstract "Monoclonal antibodies that react with defined regions of the heavy and light chains of chicken skeletal muscle myosin have been used to provide a correlation between the primary and the tertiary structures of the head. Electron microscopy of rotary shadowed antibody-myosin complexes shows that the sites for three epitopes in the 25,000 Mr tryptic fragment (25k) of subfragment-1, including one within 4000 Mr of the amino terminus of the myosin heavy chain, are clustered 145(±20) Å from the head-rod junction. An epitope in the 50,000 Mr fragment maps even further out on the head. These antibodies bind to the head in several orientations, suggesting that each of the heads can rotate 180° about the head-rod junction. The epitopes are accessible on subfragment-1 bound to actin when they were probed with Fab fragments; therefore, none of these heavy chain sites is on the contact surface between the head and actin. Two of the anti-25k antibodies affect the K+-EDTA- and Ca2+-ATPase activities of myosin in a manner that mimics the effect on activity of the modification of the reactive thiol, SH-1. These two antibodies also inhibit the actin-activated ATPase non-competitively with respect to actin. None of the other eight antibodies tested had any marked effect on activity. A monoclonal antibody that reacts with an epitope in the amino-terminal third of myosin light chain 2 maps close to the head-rod junction. A polyclonal antibody specific for the amino terminus of light chain 3 binds further up in the “neck region” of the head, indicating that these portions of the two classes of light chains are located at different sites." @default.
• W1990379370 created "2016-06-24" @default.
• W1990379370 creator A5007001742 @default.
• W1990379370 creator A5084134263 @default.
• W1990379370 date "1986-04-01" @default.
• W1990379370 modified "2023-10-14" @default.
• W1990379370 title "Probing myosin head structure with monoclonal antibodies" @default.
• W1990379370 cites W124504601 @default.
• W1990379370 cites W1474627380 @default.
• W1990379370 cites W1507106534 @default.
• W1990379370 cites W1532493403 @default.
• W1990379370 cites W1533173993 @default.
• W1990379370 cites W1538692246 @default.
• W1990379370 cites W1569313009 @default.
• W1990379370 cites W1570910952 @default.
• W1990379370 cites W1584259705 @default.
• W1990379370 cites W1593102911 @default.
• W1990379370 cites W1965659374 @default.
• W1990379370 cites W1974974023 @default.
• W1990379370 cites W1977461031 @default.
• W1990379370 cites W1977701526 @default.
• W1990379370 cites W1979304607 @default.
• W1990379370 cites W1980698686 @default.
• W1990379370 cites W1982867922 @default.
• W1990379370 cites W1984670911 @default.
• W1990379370 cites W1984684797 @default.
• W1990379370 cites W1986049053 @default.
• W1990379370 cites W1987589427 @default.
• W1990379370 cites W1991181780 @default.
• W1990379370 cites W1992499210 @default.
• W1990379370 cites W1994054808 @default.
• W1990379370 cites W2009649815 @default.
• W1990379370 cites W2009985397 @default.
• W1990379370 cites W2014113999 @default.
• W1990379370 cites W2016825470 @default.
• W1990379370 cites W2022907543 @default.
• W1990379370 cites W2023519337 @default.
• W1990379370 cites W2024636412 @default.
• W1990379370 cites W2030705265 @default.
• W1990379370 cites W2033330820 @default.
• W1990379370 cites W2037150428 @default.
• W1990379370 cites W2037710668 @default.
• W1990379370 cites W2045720938 @default.
• W1990379370 cites W2045913132 @default.
• W1990379370 cites W2058321065 @default.
• W1990379370 cites W2065823734 @default.
• W1990379370 cites W2067432542 @default.
• W1990379370 cites W2072529314 @default.
• W1990379370 cites W2073883999 @default.
• W1990379370 cites W2074118184 @default.
• W1990379370 cites W2077074448 @default.
• W1990379370 cites W2086730251 @default.
• W1990379370 cites W2093163521 @default.
• W1990379370 cites W2093695555 @default.
• W1990379370 cites W2100837269 @default.
• W1990379370 cites W2103337427 @default.
• W1990379370 cites W2139292873 @default.
• W1990379370 cites W2156395378 @default.
• W1990379370 cites W2232456525 @default.
• W1990379370 cites W2279642565 @default.
• W1990379370 doi "https://doi.org/10.1016/s0022-2836(86)80009-2" @default.
• W1990379370 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2942700" @default.
• W1990379370 hasPublicationYear "1986" @default.
• W1990379370 type Work @default.
• W1990379370 sameAs 1990379370 @default.
• W1990379370 citedByCount "100" @default.
• W1990379370 countsByYear W19903793702013 @default.
• W1990379370 countsByYear W19903793702018 @default.
• W1990379370 crossrefType "journal-article" @default.
• W1990379370 hasAuthorship W1990379370A5007001742 @default.
• W1990379370 hasAuthorship W1990379370A5084134263 @default.
• W1990379370 hasConcept C12554922 @default.
• W1990379370 hasConcept C125705527 @default.
• W1990379370 hasConcept C153911025 @default.
• W1990379370 hasConcept C15954220 @default.
• W1990379370 hasConcept C159654299 @default.
• W1990379370 hasConcept C181199279 @default.
• W1990379370 hasConcept C185592680 @default.
• W1990379370 hasConcept C195616568 @default.
• W1990379370 hasConcept C23265538 @default.
• W1990379370 hasConcept C36394416 @default.
• W1990379370 hasConcept C542903549 @default.
• W1990379370 hasConcept C54355233 @default.
• W1990379370 hasConcept C55493867 @default.
• W1990379370 hasConcept C6997183 @default.
• W1990379370 hasConcept C8035138 @default.
• W1990379370 hasConcept C86803240 @default.
• W1990379370 hasConcept C956191 @default.
• W1990379370 hasConceptScore W1990379370C12554922 @default.
• W1990379370 hasConceptScore W1990379370C125705527 @default.
• W1990379370 hasConceptScore W1990379370C153911025 @default.
• W1990379370 hasConceptScore W1990379370C15954220 @default.
• W1990379370 hasConceptScore W1990379370C159654299 @default.
• W1990379370 hasConceptScore W1990379370C181199279 @default.
• W1990379370 hasConceptScore W1990379370C185592680 @default.
• W1990379370 hasConceptScore W1990379370C195616568 @default.
• W1990379370 hasConceptScore W1990379370C23265538 @default.
• W1990379370 hasConceptScore W1990379370C36394416 @default.

• next