FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990384268> ?p ?o ?g. }

• W1990384268 endingPage "338" @default.
• W1990384268 startingPage "328" @default.
• W1990384268 abstract "Pin1 protein is a peptidyl-prolyl cis-trans isomerase that modulates the activity of a range of proteins involved in cell function. We and others have demonstrated neuronal Pin1 deficits in Alzheimer's disease (AD) and have shown similar deficits in frontotemporal dementia and in aging. Pin1 may, in fact, be a susceptibility factor; others have shown that Pin1 depletion causes apoptosis in HeLa cells. Further, patterns of AD pathology correlate with regions of lower Pin1 expression in normal human brain; Pin1 knockout mice suffer neurodegeneration; and Pin1 can ameliorate p-tau pathology by isomerizing p-tau, facilitating its trans-specific dephosphorylation and restoring its ability to bind to and restabilize microtubules and thence cytoskeletal integrity. Here, we report a novel localization of high levels of Pin1 with lipofuscin in aging neurons. This association could progressively drain available Pin1 and be deleterious to neuronal function during aging. We also show that Pin1 associates with lipofuscin when lipofuscin accumulations become marked and correlate with susceptibility to neurodegenerative disease. Our data are consistent with the possibility that neuronal Pin1 deficits may be a contributory factor in neurodegeneration associated with aging." @default.
• W1990384268 created "2016-06-24" @default.
• W1990384268 creator A5028450822 @default.
• W1990384268 creator A5060240000 @default.
• W1990384268 creator A5068799152 @default.
• W1990384268 creator A5072010327 @default.
• W1990384268 creator A5064883488 @default.
• W1990384268 date "2006-06-01" @default.
• W1990384268 modified "2023-10-13" @default.
• W1990384268 title "Pin1 protein associates with neuronal lipofuscin: Potential consequences in age-related neurodegeneration" @default.
• W1990384268 cites W139196274 @default.
• W1990384268 cites W149130878 @default.
• W1990384268 cites W1538904872 @default.
• W1990384268 cites W1541944730 @default.
• W1990384268 cites W1965113049 @default.
• W1990384268 cites W1968069432 @default.
• W1990384268 cites W1972370280 @default.
• W1990384268 cites W1981149222 @default.
• W1990384268 cites W1983119108 @default.
• W1990384268 cites W1990623524 @default.
• W1990384268 cites W2000830026 @default.
• W1990384268 cites W2012221118 @default.
• W1990384268 cites W2023677185 @default.
• W1990384268 cites W2024215142 @default.
• W1990384268 cites W2025822436 @default.
• W1990384268 cites W2027003108 @default.
• W1990384268 cites W2045180417 @default.
• W1990384268 cites W2045295833 @default.
• W1990384268 cites W2045437422 @default.
• W1990384268 cites W2046078109 @default.
• W1990384268 cites W2050554045 @default.
• W1990384268 cites W2061368959 @default.
• W1990384268 cites W2065993271 @default.
• W1990384268 cites W2081055723 @default.
• W1990384268 cites W2083398163 @default.
• W1990384268 cites W2086751197 @default.
• W1990384268 cites W2088164258 @default.
• W1990384268 cites W2095513500 @default.
• W1990384268 cites W2096714694 @default.
• W1990384268 cites W2097389952 @default.
• W1990384268 cites W2108638303 @default.
• W1990384268 cites W2113007696 @default.
• W1990384268 cites W2153211616 @default.
• W1990384268 cites W2162316101 @default.
• W1990384268 doi "https://doi.org/10.1016/j.expneurol.2005.12.030" @default.
• W1990384268 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16480979" @default.
• W1990384268 hasPublicationYear "2006" @default.
• W1990384268 type Work @default.
• W1990384268 sameAs 1990384268 @default.
• W1990384268 citedByCount "18" @default.
• W1990384268 countsByYear W19903842682013 @default.
• W1990384268 countsByYear W19903842682014 @default.
• W1990384268 countsByYear W19903842682015 @default.
• W1990384268 countsByYear W19903842682017 @default.
• W1990384268 countsByYear W19903842682018 @default.
• W1990384268 countsByYear W19903842682019 @default.
• W1990384268 countsByYear W19903842682023 @default.
• W1990384268 crossrefType "journal-article" @default.
• W1990384268 hasAuthorship W1990384268A5028450822 @default.
• W1990384268 hasAuthorship W1990384268A5060240000 @default.
• W1990384268 hasAuthorship W1990384268A5064883488 @default.
• W1990384268 hasAuthorship W1990384268A5068799152 @default.
• W1990384268 hasAuthorship W1990384268A5072010327 @default.
• W1990384268 hasConcept C104317684 @default.
• W1990384268 hasConcept C142724271 @default.
• W1990384268 hasConcept C154472170 @default.
• W1990384268 hasConcept C169760540 @default.
• W1990384268 hasConcept C186198217 @default.
• W1990384268 hasConcept C2776925932 @default.
• W1990384268 hasConcept C2778641062 @default.
• W1990384268 hasConcept C2779134260 @default.
• W1990384268 hasConcept C2779483572 @default.
• W1990384268 hasConcept C2781264208 @default.
• W1990384268 hasConcept C2910677434 @default.
• W1990384268 hasConcept C55493867 @default.
• W1990384268 hasConcept C71924100 @default.
• W1990384268 hasConcept C86803240 @default.
• W1990384268 hasConcept C95444343 @default.
• W1990384268 hasConceptScore W1990384268C104317684 @default.
• W1990384268 hasConceptScore W1990384268C142724271 @default.
• W1990384268 hasConceptScore W1990384268C154472170 @default.
• W1990384268 hasConceptScore W1990384268C169760540 @default.
• W1990384268 hasConceptScore W1990384268C186198217 @default.
• W1990384268 hasConceptScore W1990384268C2776925932 @default.
• W1990384268 hasConceptScore W1990384268C2778641062 @default.
• W1990384268 hasConceptScore W1990384268C2779134260 @default.
• W1990384268 hasConceptScore W1990384268C2779483572 @default.
• W1990384268 hasConceptScore W1990384268C2781264208 @default.
• W1990384268 hasConceptScore W1990384268C2910677434 @default.
• W1990384268 hasConceptScore W1990384268C55493867 @default.
• W1990384268 hasConceptScore W1990384268C71924100 @default.
• W1990384268 hasConceptScore W1990384268C86803240 @default.
• W1990384268 hasConceptScore W1990384268C95444343 @default.
• W1990384268 hasIssue "2" @default.
• W1990384268 hasLocation W19903842681 @default.
• W1990384268 hasLocation W19903842682 @default.
• W1990384268 hasOpenAccess W1990384268 @default.
• W1990384268 hasPrimaryLocation W19903842681 @default.

• next