FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990385436> ?p ?o ?g. }

• W1990385436 endingPage "4698" @default.
• W1990385436 startingPage "4693" @default.
• W1990385436 abstract "Relatively little is understood about the dynamics of global host-pathogen transcriptome changes that occur during bacterial infection of mucosal surfaces. To test the hypothesis that group A Streptococcus (GAS) infection of the oropharynx provokes a distinct host transcriptome response, we performed genome-wide transcriptome analysis using a nonhuman primate model of experimental pharyngitis. We also identified host and pathogen biological processes and individual host and pathogen gene pairs with correlated patterns of expression, suggesting interaction. For this study, 509 host genes and seven biological pathways were differentially expressed throughout the entire 32-day infection cycle. GAS infection produced an initial widespread significant decrease in expression of many host genes, including those involved in cytokine production, vesicle formation, metabolism, and signal transduction. This repression lasted until day 4, at which time a large increase in expression of host genes was observed, including those involved in protein translation, antigen presentation, and GTP-mediated signaling. The interactome analysis identified 73 host and pathogen gene pairs with correlated expression levels. We discovered significant correlations between transcripts of GAS genes involved in hyaluronic capsule production and host endocytic vesicle formation, GAS GTPases and host fibrinolytic genes, and GAS response to interaction with neutrophils. We also identified a strong signal, suggesting interaction between host gammadelta T cells and genes in the GAS mevalonic acid synthesis pathway responsible for production of isopentenyl-pyrophosphate, a short-chain phospholipid that stimulates these T cells. Taken together, our results are unique in providing a comprehensive understanding of the host-pathogen interactome during mucosal infection by a bacterial pathogen." @default.
• W1990385436 created "2016-06-24" @default.
• W1990385436 creator A5001771689 @default.
• W1990385436 creator A5006099075 @default.
• W1990385436 creator A5010204053 @default.
• W1990385436 creator A5013411729 @default.
• W1990385436 creator A5013763314 @default.
• W1990385436 creator A5016238665 @default.
• W1990385436 creator A5016392959 @default.
• W1990385436 creator A5039620453 @default.
• W1990385436 creator A5056332354 @default.
• W1990385436 creator A5062303919 @default.
• W1990385436 creator A5063695159 @default.
• W1990385436 creator A5066873624 @default.
• W1990385436 creator A5073856506 @default.
• W1990385436 creator A5075662505 @default.
• W1990385436 creator A5079337385 @default.
• W1990385436 creator A5080432457 @default.
• W1990385436 creator A5081046143 @default.
• W1990385436 creator A5084785027 @default.
• W1990385436 creator A5088735539 @default.
• W1990385436 date "2010-03-09" @default.
• W1990385436 modified "2023-09-23" @default.
• W1990385436 title "Interactome analysis of longitudinal pharyngeal infection of cynomolgus macaques by group A <i>Streptococcus</i>" @default.
• W1990385436 cites W1535243328 @default.
• W1990385436 cites W1928920266 @default.
• W1990385436 cites W1968587304 @default.
• W1990385436 cites W1980708527 @default.
• W1990385436 cites W1981756981 @default.
• W1990385436 cites W1994164940 @default.
• W1990385436 cites W2003301330 @default.
• W1990385436 cites W2004140618 @default.
• W1990385436 cites W2009715560 @default.
• W1990385436 cites W2009751329 @default.
• W1990385436 cites W2011862459 @default.
• W1990385436 cites W2012372286 @default.
• W1990385436 cites W2013563704 @default.
• W1990385436 cites W2032526817 @default.
• W1990385436 cites W2041483436 @default.
• W1990385436 cites W2044565392 @default.
• W1990385436 cites W2058846847 @default.
• W1990385436 cites W2069419313 @default.
• W1990385436 cites W2078064760 @default.
• W1990385436 cites W2080467264 @default.
• W1990385436 cites W2088422296 @default.
• W1990385436 cites W2092579362 @default.
• W1990385436 cites W2101998831 @default.
• W1990385436 cites W2107698516 @default.
• W1990385436 cites W2119583218 @default.
• W1990385436 cites W2122683221 @default.
• W1990385436 cites W2129035692 @default.
• W1990385436 cites W2135363028 @default.
• W1990385436 cites W2139036189 @default.
• W1990385436 cites W2139119391 @default.
• W1990385436 cites W2139969153 @default.
• W1990385436 cites W2145207673 @default.
• W1990385436 cites W2149880504 @default.
• W1990385436 cites W2150207336 @default.
• W1990385436 cites W2150986328 @default.
• W1990385436 cites W2167349522 @default.
• W1990385436 doi "https://doi.org/10.1073/pnas.0906384107" @default.
• W1990385436 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2842040" @default.
• W1990385436 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20179180" @default.
• W1990385436 hasPublicationYear "2010" @default.
• W1990385436 type Work @default.
• W1990385436 sameAs 1990385436 @default.
• W1990385436 citedByCount "29" @default.
• W1990385436 countsByYear W19903854362012 @default.
• W1990385436 countsByYear W19903854362013 @default.
• W1990385436 countsByYear W19903854362014 @default.
• W1990385436 countsByYear W19903854362015 @default.
• W1990385436 countsByYear W19903854362017 @default.
• W1990385436 countsByYear W19903854362019 @default.
• W1990385436 countsByYear W19903854362020 @default.
• W1990385436 countsByYear W19903854362021 @default.
• W1990385436 crossrefType "journal-article" @default.
• W1990385436 hasAuthorship W1990385436A5001771689 @default.
• W1990385436 hasAuthorship W1990385436A5006099075 @default.
• W1990385436 hasAuthorship W1990385436A5010204053 @default.
• W1990385436 hasAuthorship W1990385436A5013411729 @default.
• W1990385436 hasAuthorship W1990385436A5013763314 @default.
• W1990385436 hasAuthorship W1990385436A5016238665 @default.
• W1990385436 hasAuthorship W1990385436A5016392959 @default.
• W1990385436 hasAuthorship W1990385436A5039620453 @default.
• W1990385436 hasAuthorship W1990385436A5056332354 @default.
• W1990385436 hasAuthorship W1990385436A5062303919 @default.
• W1990385436 hasAuthorship W1990385436A5063695159 @default.
• W1990385436 hasAuthorship W1990385436A5066873624 @default.
• W1990385436 hasAuthorship W1990385436A5073856506 @default.
• W1990385436 hasAuthorship W1990385436A5075662505 @default.
• W1990385436 hasAuthorship W1990385436A5079337385 @default.
• W1990385436 hasAuthorship W1990385436A5080432457 @default.
• W1990385436 hasAuthorship W1990385436A5081046143 @default.
• W1990385436 hasAuthorship W1990385436A5084785027 @default.
• W1990385436 hasAuthorship W1990385436A5088735539 @default.
• W1990385436 hasBestOaLocation W19903854361 @default.
• W1990385436 hasConcept C104317684 @default.
• W1990385436 hasConcept C150194340 @default.

• next