Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990385611> ?p ?o ?g. }
- W1990385611 endingPage "2195" @default.
- W1990385611 startingPage "2189" @default.
- W1990385611 abstract "Abstract Hereditary hemochromatosis (HH), an iron overload disease associated with mutations in the HFE gene, is characterized by increased intestinal iron absorption and consequent deposition of excess iron, primarily in the liver. Patients with HH and Hfe-deficient (Hfe-/-) mice manifest inappropriate expression of the iron absorption regulator hepcidin, a peptide hormone produced by the liver in response to iron loading. In this study, we investigated the contribution of Hfe expression in macrophages to the regulation of liver hepcidin levels and iron loading. We used bone marrow transplantation to generate wild-type (wt) and Hfe-/- mice chimeric for macrophage Hfe gene expression. Reconstitution of Hfe-deficient mice with wt bone marrow resulted in augmented capacity of the spleen to store iron and in significantly decreased liver iron loading, accompanied by a significant increase of hepatic hepcidin mRNA levels. Conversely, wt mice reconstituted with Hfe-deficient bone marrow had a diminished capacity to store iron in the spleen but no significant alterations of liver iron stores or hepcidin mRNA levels. Our results suggest that macrophage Hfe participates in the regulation of splenic and liver iron concentrations and liver hepcidin expression. (Blood. 2005;106:2189-2195)" @default.
- W1990385611 created "2016-06-24" @default.
- W1990385611 creator A5027101617 @default.
- W1990385611 creator A5054512866 @default.
- W1990385611 creator A5070135369 @default.
- W1990385611 creator A5078196044 @default.
- W1990385611 creator A5079759786 @default.
- W1990385611 date "2005-09-15" @default.
- W1990385611 modified "2023-10-12" @default.
- W1990385611 title "Contribution of Hfe expression in macrophages to the regulation of hepatic hepcidin levels and iron loading" @default.
- W1990385611 cites W121649675 @default.
- W1990385611 cites W1510811131 @default.
- W1990385611 cites W1525515545 @default.
- W1990385611 cites W1532911485 @default.
- W1990385611 cites W1542326554 @default.
- W1990385611 cites W1564167460 @default.
- W1990385611 cites W15887191 @default.
- W1990385611 cites W1857613114 @default.
- W1990385611 cites W1972112344 @default.
- W1990385611 cites W1974570930 @default.
- W1990385611 cites W1980042430 @default.
- W1990385611 cites W1982022033 @default.
- W1990385611 cites W1989376893 @default.
- W1990385611 cites W1990330893 @default.
- W1990385611 cites W2000156766 @default.
- W1990385611 cites W2002605005 @default.
- W1990385611 cites W2003728529 @default.
- W1990385611 cites W2018391935 @default.
- W1990385611 cites W2025063713 @default.
- W1990385611 cites W2027264065 @default.
- W1990385611 cites W2037511711 @default.
- W1990385611 cites W2042723976 @default.
- W1990385611 cites W2043254960 @default.
- W1990385611 cites W2046312528 @default.
- W1990385611 cites W2048258494 @default.
- W1990385611 cites W2050531443 @default.
- W1990385611 cites W2053820570 @default.
- W1990385611 cites W2055631866 @default.
- W1990385611 cites W2059080581 @default.
- W1990385611 cites W2062219788 @default.
- W1990385611 cites W2083569219 @default.
- W1990385611 cites W2087744489 @default.
- W1990385611 cites W2090165219 @default.
- W1990385611 cites W2090868713 @default.
- W1990385611 cites W2094352563 @default.
- W1990385611 cites W2099335802 @default.
- W1990385611 cites W2099642944 @default.
- W1990385611 cites W2101882602 @default.
- W1990385611 cites W2136658802 @default.
- W1990385611 cites W2141937988 @default.
- W1990385611 cites W2145306168 @default.
- W1990385611 cites W2145661576 @default.
- W1990385611 cites W2148362837 @default.
- W1990385611 cites W2150567434 @default.
- W1990385611 cites W2156032604 @default.
- W1990385611 cites W2159316975 @default.
- W1990385611 cites W2161195938 @default.
- W1990385611 cites W2161918511 @default.
- W1990385611 cites W2161998284 @default.
- W1990385611 cites W2164698647 @default.
- W1990385611 cites W2170914662 @default.
- W1990385611 cites W2415657389 @default.
- W1990385611 cites W284603049 @default.
- W1990385611 cites W4243766541 @default.
- W1990385611 cites W4255500373 @default.
- W1990385611 cites W67604591 @default.
- W1990385611 doi "https://doi.org/10.1182/blood-2005-02-0629" @default.
- W1990385611 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2891009" @default.
- W1990385611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15914561" @default.
- W1990385611 hasPublicationYear "2005" @default.
- W1990385611 type Work @default.
- W1990385611 sameAs 1990385611 @default.
- W1990385611 citedByCount "64" @default.
- W1990385611 countsByYear W19903856112012 @default.
- W1990385611 countsByYear W19903856112013 @default.
- W1990385611 countsByYear W19903856112014 @default.
- W1990385611 countsByYear W19903856112015 @default.
- W1990385611 countsByYear W19903856112017 @default.
- W1990385611 countsByYear W19903856112018 @default.
- W1990385611 countsByYear W19903856112019 @default.
- W1990385611 countsByYear W19903856112020 @default.
- W1990385611 countsByYear W19903856112021 @default.
- W1990385611 countsByYear W19903856112022 @default.
- W1990385611 countsByYear W19903856112023 @default.
- W1990385611 crossrefType "journal-article" @default.
- W1990385611 hasAuthorship W1990385611A5027101617 @default.
- W1990385611 hasAuthorship W1990385611A5054512866 @default.
- W1990385611 hasAuthorship W1990385611A5070135369 @default.
- W1990385611 hasAuthorship W1990385611A5078196044 @default.
- W1990385611 hasAuthorship W1990385611A5079759786 @default.
- W1990385611 hasBestOaLocation W19903856111 @default.
- W1990385611 hasConcept C126322002 @default.
- W1990385611 hasConcept C134018914 @default.
- W1990385611 hasConcept C185592680 @default.
- W1990385611 hasConcept C2776590208 @default.
- W1990385611 hasConcept C2776710925 @default.
- W1990385611 hasConcept C2776768029 @default.
- W1990385611 hasConcept C2778248108 @default.