FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990385730> ?p ?o ?g. }

• W1990385730 endingPage "4838" @default.
• W1990385730 startingPage "4832" @default.
• W1990385730 abstract "Abstract Both CD4+ T cells and macrophages are major reservoirs of HIV-1. Previous study showed that HIV-1–specific cytolytic T lymphocytes (CTLs) hardly recognize HIV-1–infected CD4+ T cells because of Nef-mediated HLA class I down-regulation, suggesting that HIV-1 escapes from HIV-1–specific CTLs and continues to replicate in HIV-1–infected donors. On the other hand, the CTL recognition of HIV-1–infected macrophages and the effect of Nef-mediated HLA class I down-regulation on this recognition still remain unclear. We show a strong HIV-1 antigen presentation by HIV-1–infected macrophages. HIV-1–specific CTLs had strong abilities to suppress HIV-1R5 virus replication in HIV-1–infected macrophages and to kill HIV-1R5–infected macrophages. Nef-mediated HLA class I down-regulation minimally influenced the recognition of HIV-1–infected macrophages by HIV-1–specific CTLs. In addition, HIV-1–infected macrophages had a stronger ability to stimulate the proliferation of HIV-1–specific CTLs than HIV-1–infected CD4+ T cells. Thus, the effect of Nef-mediated HLA class I down-regulation was less critical with respect to the recognition by HIV-1–specific CTLs of HIV-infected macrophages than that of HIV-1–infected CD4+ T cells. These findings support the idea that the strong HIV-1 antigen presentation by HIV-1–infected macrophages is one of the mechanisms mediating effective induction of HIV-1–specific CTLs in the acute and early chronic phases of HIV-1 infection." @default.
• W1990385730 created "2016-06-24" @default.
• W1990385730 creator A5070884320 @default.
• W1990385730 creator A5078546233 @default.
• W1990385730 date "2007-06-01" @default.
• W1990385730 modified "2023-09-30" @default.
• W1990385730 title "HIV-1–specific CTLs effectively suppress replication of HIV-1 in HIV-1–infected macrophages" @default.
• W1990385730 cites W1479742935 @default.
• W1990385730 cites W1655510925 @default.
• W1990385730 cites W1661544713 @default.
• W1990385730 cites W1674854702 @default.
• W1990385730 cites W1714666634 @default.
• W1990385730 cites W1928100000 @default.
• W1990385730 cites W1945834141 @default.
• W1990385730 cites W1975896814 @default.
• W1990385730 cites W2022098233 @default.
• W1990385730 cites W2025481552 @default.
• W1990385730 cites W2030692398 @default.
• W1990385730 cites W2030844138 @default.
• W1990385730 cites W2037343680 @default.
• W1990385730 cites W2041204705 @default.
• W1990385730 cites W2063964903 @default.
• W1990385730 cites W2066121768 @default.
• W1990385730 cites W2071459721 @default.
• W1990385730 cites W2073125718 @default.
• W1990385730 cites W2082814103 @default.
• W1990385730 cites W2085919513 @default.
• W1990385730 cites W2097295476 @default.
• W1990385730 cites W2108381430 @default.
• W1990385730 cites W2111220263 @default.
• W1990385730 cites W2129114331 @default.
• W1990385730 cites W2160030189 @default.
• W1990385730 cites W2163237181 @default.
• W1990385730 cites W2163386497 @default.
• W1990385730 cites W2167344136 @default.
• W1990385730 cites W2171034382 @default.
• W1990385730 cites W2177327503 @default.
• W1990385730 cites W2326236783 @default.
• W1990385730 cites W2339085593 @default.
• W1990385730 cites W90568390 @default.
• W1990385730 cites W2062650446 @default.
• W1990385730 doi "https://doi.org/10.1182/blood-2006-07-037481" @default.
• W1990385730 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17303696" @default.
• W1990385730 hasPublicationYear "2007" @default.
• W1990385730 type Work @default.
• W1990385730 sameAs 1990385730 @default.
• W1990385730 citedByCount "34" @default.
• W1990385730 countsByYear W19903857302012 @default.
• W1990385730 countsByYear W19903857302014 @default.
• W1990385730 countsByYear W19903857302015 @default.
• W1990385730 countsByYear W19903857302016 @default.
• W1990385730 countsByYear W19903857302018 @default.
• W1990385730 countsByYear W19903857302019 @default.
• W1990385730 countsByYear W19903857302020 @default.
• W1990385730 countsByYear W19903857302022 @default.
• W1990385730 crossrefType "journal-article" @default.
• W1990385730 hasAuthorship W1990385730A5070884320 @default.
• W1990385730 hasAuthorship W1990385730A5078546233 @default.
• W1990385730 hasBestOaLocation W19903857301 @default.
• W1990385730 hasConcept C140704245 @default.
• W1990385730 hasConcept C147483822 @default.
• W1990385730 hasConcept C147969180 @default.
• W1990385730 hasConcept C154317977 @default.
• W1990385730 hasConcept C159047783 @default.
• W1990385730 hasConcept C167672396 @default.
• W1990385730 hasConcept C188280979 @default.
• W1990385730 hasConcept C202751555 @default.
• W1990385730 hasConcept C203014093 @default.
• W1990385730 hasConcept C2522874641 @default.
• W1990385730 hasConcept C2776090121 @default.
• W1990385730 hasConcept C2779244956 @default.
• W1990385730 hasConcept C2780727368 @default.
• W1990385730 hasConcept C2910359755 @default.
• W1990385730 hasConcept C3013748606 @default.
• W1990385730 hasConcept C55493867 @default.
• W1990385730 hasConcept C71924100 @default.
• W1990385730 hasConcept C73588182 @default.
• W1990385730 hasConcept C83464605 @default.
• W1990385730 hasConcept C86803240 @default.
• W1990385730 hasConcept C8891405 @default.
• W1990385730 hasConceptScore W1990385730C140704245 @default.
• W1990385730 hasConceptScore W1990385730C147483822 @default.
• W1990385730 hasConceptScore W1990385730C147969180 @default.
• W1990385730 hasConceptScore W1990385730C154317977 @default.
• W1990385730 hasConceptScore W1990385730C159047783 @default.
• W1990385730 hasConceptScore W1990385730C167672396 @default.
• W1990385730 hasConceptScore W1990385730C188280979 @default.
• W1990385730 hasConceptScore W1990385730C202751555 @default.
• W1990385730 hasConceptScore W1990385730C203014093 @default.
• W1990385730 hasConceptScore W1990385730C2522874641 @default.
• W1990385730 hasConceptScore W1990385730C2776090121 @default.
• W1990385730 hasConceptScore W1990385730C2779244956 @default.
• W1990385730 hasConceptScore W1990385730C2780727368 @default.
• W1990385730 hasConceptScore W1990385730C2910359755 @default.
• W1990385730 hasConceptScore W1990385730C3013748606 @default.
• W1990385730 hasConceptScore W1990385730C55493867 @default.
• W1990385730 hasConceptScore W1990385730C71924100 @default.
• W1990385730 hasConceptScore W1990385730C73588182 @default.

• next