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• W1990386712 abstract "Three new decalin-type tetramic acid analogues, pyrrolocins A (1), B (2), and C (3), were defined as products of a metabolic pathway from a fern endophyte, NRRL 50135, from Papua New Guinea. NRRL 50135 initially produced 1 but ceased its production before chemical or biological evaluation could be completed. Upon transfer of the biosynthetic pathway to a model host, 1-3 were produced. All three compounds are structurally related to equisetin-type compounds, with 1 and 3 having a trans-decalin ring system, while 2 has a cis-fused decalin. All were active against Mycobacterium tuberculosis, with the trans-decalin analogues 1 and 3 exhibiting lower MICs than the cis-decalin analogue 2. Here we report the isolation, structure elucidation, and antimycobacterial activities of 1-3 from the recombinant expression as well as the isolation of 1 from the wild-type fungus NRRL 50135." @default.
• W1990386712 created "2016-06-24" @default.
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• W1990386712 date "2014-10-29" @default.
• W1990386712 modified "2023-10-16" @default.
• W1990386712 title "Isolation of Pyrrolocins A–C: <i>cis</i>- and <i>trans</i>-Decalin Tetramic Acid Antibiotics from an Endophytic Fungal-Derived Pathway" @default.
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• W1990386712 doi "https://doi.org/10.1021/np500617u" @default.
• W1990386712 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4251065" @default.
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