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• W1990389323 abstract "Neurons receive thousands of synaptic inputs throughout elaborate dendritic trees. Here we determine the somatic impact of excitatory postsynaptic potentials (EPSPs) generated at known dendritic sites in neocortical pyramidal neurons. As inputs became more distal, somatic EPSP amplitude decreased, whereas use-dependent depression increased. Despite marked attenuation (>40-fold), when coactivated within a narrow time window (∼10 milliseconds), distal EPSPs could directly influence action potential output following dendritic spike generation. These findings reveal that distal EPSPs are ineffective sources of background somatic excitation, but through coincidence detection have a powerful transient signaling role." @default.
• W1990389323 created "2016-06-24" @default.
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• W1990389323 date "2002-03-08" @default.
• W1990389323 modified "2023-10-16" @default.
• W1990389323 title "Dependence of EPSP Efficacy on Synapse Location in Neocortical Pyramidal Neurons" @default.
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• W1990389323 doi "https://doi.org/10.1126/science.1067903" @default.
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