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- W1990390216 abstract "Progesterone induces G 2 -arrested Xenopus oocytes to develop into fertilizable eggs in a process called meiotic maturation. Protein kinase A (PKA), the cAMP-dependent protein kinase, has long been known to be a potent inhibitor of meiotic maturation, but little information is available on how PKA functions. We have cloned two Xenopus PKA catalytic subunit isoforms, XPKAα and XPKAβ. These proteins are 89% identical and both inhibit progesterone-induced meiotic maturation when overexpressed at low levels, suggesting that PKA activity is tightly regulated in the oocyte. Unexpectedly, catalytically inactive XPKA mutants are able to block progesterone-induced maturation as efficiently as the wild-type active XPKA. These mutants also block meiotic maturation induced by Mos, but are less efficient at inhibiting Cdc25C-induced maturation. Our results indicate that PKA can inhibit meiotic maturation by a novel mechanism, which does not require its kinase activity and is also independent of binding to the PKA regulatory subunits." @default.
- W1990390216 created "2016-06-24" @default.
- W1990390216 creator A5058080722 @default.
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- W1990390216 date "2002-03-19" @default.
- W1990390216 modified "2023-10-17" @default.
- W1990390216 title "Inhibition of <i>Xenopus</i> oocyte meiotic maturation by catalytically inactive protein kinase A" @default.
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- W1990390216 doi "https://doi.org/10.1073/pnas.022056399" @default.
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