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• W1990392907 abstract "A quantitative hypothesis is developed to explain the cytotoxic action of chemical mutagens on eukaryotic cells. The hypothesis forms an extrapolation of previously developed concepts used to explain the effect of ionizing radiation and the cytotoxic action of UV light. The crucial potentially lethal lesion is assumed to be a DNA double-strand lesion which may be an interstrand cross-link or a pair of DNA single-strand alkylations, for example. The effect of repair processes is included in the analytical equation derived to describe cell survival. The analysis of several sets of cell survival data for different chemical mutagens is used to demonstrate the applicability of the hypothesis. The logical extension of the hypothesis permits a division of chemical mutagens into 4 separate classes on the basis of the mechanisms proposed for the cytotoxic activity, and the relative importance of the risk associated with low-level exposure to each class is discussed. The hypothesis is amenable to further experimental verification." @default.
• W1990392907 created "2016-06-24" @default.
• W1990392907 creator A5001289606 @default.
• W1990392907 creator A5063881995 @default.
• W1990392907 date "1984-12-01" @default.
• W1990392907 modified "2023-10-01" @default.
• W1990392907 title "A quantitative analysis of the cytotoxic action of chemical mutagens" @default.
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• W1990392907 doi "https://doi.org/10.1016/0027-5107(84)90089-7" @default.
• W1990392907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6513962" @default.
• W1990392907 hasPublicationYear "1984" @default.
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