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- W1990392912 abstract "Abstract The effects of methamphetamine (MAP) on crayfish opener muscle were investigated. In concentrations larger than 10−4 m MAP decreased the amplitude of excitatory and inhibitory junctional potentials and shortened the falling phase of the excitatory junctional potential. In a concentration of 10−3 m MAP had little effect on the process of facilitation of the excitatory junctional potentials. Methamphetamine depressed the depolarizing action of glutamate and decreased the input resistance of the crayfish opener muscle fibre. Sodium, Ca2+ and Cl− ions had little relation to the conductance increase caused by MAP. In the K+-free solution, MAP produced only a small decrease in the input resistance. The membrane potential of the muscle fibres was changed by alterations in external K+ concentration of the bathing solution. As external K+ concentration became lower, the deviation of the membrane potential from the potassium equilibrium potential became remarkable in the normal solution. However, in the MAP-containing solution, the membrane potential approached equilibrium potential for K+. These results suggest that MAP selectively increases the K+ permeability of the muscle membrane of the crayfish." @default.
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- W1990392912 title "Increase in potassium permeability caused by methamphetamine in crayfish opener muscle" @default.
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- W1990392912 doi "https://doi.org/10.1016/0028-3908(77)90030-2" @default.
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