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- W1990395422 abstract "Angiogenesis plays a crucial role in the pathogenesis of inflammatory diseases, including rheumatoid arthritis (RA). Therefore, targeting neovascularization in RA may hold great therapeutic potential. Several mediating factors are involved in synovial angiogenesis, including growth factors, cytokines, chemokines, adhesion molecules, and matrix-remodeling enzymes. This review aims to summarize the current understanding of these contributing factors in RA, as well as to describe both the preclinical and clinical studies in which these factors are targeted in an attempt to ameliorate the symptoms associated with RA. In addition, we highlight methods to monitor synovial angiogenesis in patients and discuss possible future therapeutic approaches in RA, including the combination of existing immunosuppressive antirheumatic therapies and anti-angiogenic treatments to potentially maximize efficacy with limited toxicity." @default.
- W1990395422 created "2016-06-24" @default.
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- W1990395422 date "2008-11-01" @default.
- W1990395422 modified "2023-09-26" @default.
- W1990395422 title "Cirrhose biliaire primitive et syndrome de chevauchement cirrhose biliaire primitive/hépatite auto-immune" @default.
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- W1990395422 doi "https://doi.org/10.1016/j.annpat.2008.09.014" @default.
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