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• W1990395804 endingPage "1477" @default.
• W1990395804 startingPage "1471" @default.
• W1990395804 abstract "To examine cross-sectional differences in insulin sensitivity, insulin secretion and β-cell function during puberty in overweight Hispanic boys and girls with a family history of type 2 diabetes. This cross-sectional, observational study included 214 8–13-y-old Hispanic children with a BMI percentile ≥85th percentile and family history of type 2 diabetes. Participants underwent a physical examination, body composition measures, oral glucose tolerance test (OGTT), and frequently-sampled intravenous glucose tolerance test. Unadjusted and adjusted general linear models (GLM) tested whether insulin/glucose dynamics differed by Tanner stage and gender. Unadjusted group comparisons showed that fasting insulin increased whereas insulin sensitivity (SI) and the disposition index (DI) (a measure of pancreatic β-cell function) decreased across Tanner stage groups (all P<0.05). No differences in the acute insulin response to glucose (AIRg), fasting glucose or 2-h glucose were found. After adjusting for covariates, there was no independent effect of Tanner stage on SI (P=0.9) or AIRg (P=0.2), but DI was slightly lower in later Tanner stages suggesting decreased β-cell function in the more mature groups (P=0.10). Overweight Hispanic children with a family history of type 2 diabetes may represent a unique population given that pubertal insulin resistance was not evident once analyses controlled for body composition. Longitudinal analyses are required to determine whether the slightly diminished β-cell function in later Tanner stages plays a role in the development of type 2 diabetes." @default.
• W1990395804 created "2016-06-24" @default.
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• W1990395804 date "2005-08-02" @default.
• W1990395804 modified "2023-10-10" @default.
• W1990395804 title "Insulin sensitivity, insulin secretion and β-cell function during puberty in overweight Hispanic children with a family history of type 2 diabetes" @default.
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• W1990395804 doi "https://doi.org/10.1038/sj.ijo.0803044" @default.
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