FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990396073> ?p ?o ?g. }

• W1990396073 abstract "Clozapine (CLZ) drug discrimination is used as a preclinical model to evaluate compounds for putative atypical antipsychotic properties. In rats, a 1.25 mg/kg CLZ training dose appears to have greater pharmacological specificity for atypical antipsychotic drugs than the traditional 5.0 mg/kg CLZ training dose; however, methodological differences among studies have precluded a direct comparison between these training doses. In the present study, rats were trained to discriminate a 5.0 mg/kg CLZ dose from vehicle in a two-choice drug discrimination task using methods similar to those in a previous study from our laboratory that used a 1.25 mg/kg CLZ training dose. Clozapine produced full substitution (≥80% CLZ-lever responding) for itself at the training dose (5.0 mg/kg). The atypical antipsychotics olanzapine, quetiapine, and ziprasidone also produced full substitution for 5.0 mg/kg CLZ, whereas the atypical antipsychotics risperidone and sertindole produced partial substitution (≥60% CLZ-lever responding). The typical antipsychotic, thioridazine, produced full substitution for the 5.0 mg/kg CLZ training dose, but the typical antipsychotics chlorpromazine, fluphenazine, and haloperidol failed to substitute for clozapine. In a subgroup of 1.25 mg/kg CLZ-trained rats, ziprasidone produced strong partial substitution (73.0 % CLZ-lever responding) for the 1.25 mg/kg CLZ training dose. Based on these findings, some atypical antipsychotic drugs (i.e., quetiapine and ziprasidone) produce full substitution only for the 5.0 mg/kg CLZ training dose, whereas other atypical antipsychotic drugs (i.e., sertindole and risperidone) produce full substitution only for the 1.25 mg/kg CLZ training dose. Thus, both of these training doses are important for the screening of putative atypical antipsychotic drugs with the clozapine drug discrimination assay. Drug Dev. Res. 64:55–65, 2005. © 2005 Wiley-Liss, Inc." @default.
• W1990396073 created "2016-06-24" @default.
• W1990396073 creator A5007209385 @default.
• W1990396073 creator A5011687572 @default.
• W1990396073 creator A5044488149 @default.
• W1990396073 creator A5067058663 @default.
• W1990396073 creator A5084663105 @default.
• W1990396073 creator A5087503029 @default.
• W1990396073 creator A5091758834 @default.
• W1990396073 date "2005-01-01" @default.
• W1990396073 modified "2023-09-24" @default.
• W1990396073 title "Generalization testing with atypical and typical antipsychotic drugs in rats trained to discriminate 5.0 mg/kg clozapine from vehicle in a two-choice drug discrimination task" @default.
• W1990396073 cites W182092392 @default.
• W1990396073 cites W1966237751 @default.
• W1990396073 cites W1968937189 @default.
• W1990396073 cites W1973757586 @default.
• W1990396073 cites W1979700184 @default.
• W1990396073 cites W1982224976 @default.
• W1990396073 cites W2005797832 @default.
• W1990396073 cites W2005957877 @default.
• W1990396073 cites W2011130132 @default.
• W1990396073 cites W2016278859 @default.
• W1990396073 cites W2022765281 @default.
• W1990396073 cites W2036841195 @default.
• W1990396073 cites W2037526863 @default.
• W1990396073 cites W2046479063 @default.
• W1990396073 cites W2050380914 @default.
• W1990396073 cites W2051238722 @default.
• W1990396073 cites W2053754882 @default.
• W1990396073 cites W2069079035 @default.
• W1990396073 cites W2069945601 @default.
• W1990396073 cites W2070917583 @default.
• W1990396073 cites W2074668691 @default.
• W1990396073 cites W2075712526 @default.
• W1990396073 cites W2079361198 @default.
• W1990396073 cites W2081181656 @default.
• W1990396073 cites W2083252023 @default.
• W1990396073 cites W2085360366 @default.
• W1990396073 cites W2090415417 @default.
• W1990396073 cites W2095213614 @default.
• W1990396073 cites W2106352416 @default.
• W1990396073 cites W2166945572 @default.
• W1990396073 cites W2171495399 @default.
• W1990396073 cites W3049811 @default.
• W1990396073 cites W4234076493 @default.
• W1990396073 cites W4242155657 @default.
• W1990396073 doi "https://doi.org/10.1002/ddr.10419" @default.
• W1990396073 hasPublicationYear "2005" @default.
• W1990396073 type Work @default.
• W1990396073 sameAs 1990396073 @default.
• W1990396073 citedByCount "8" @default.
• W1990396073 countsByYear W19903960732013 @default.
• W1990396073 countsByYear W19903960732014 @default.
• W1990396073 countsByYear W19903960732016 @default.
• W1990396073 crossrefType "journal-article" @default.
• W1990396073 hasAuthorship W1990396073A5007209385 @default.
• W1990396073 hasAuthorship W1990396073A5011687572 @default.
• W1990396073 hasAuthorship W1990396073A5044488149 @default.
• W1990396073 hasAuthorship W1990396073A5067058663 @default.
• W1990396073 hasAuthorship W1990396073A5084663105 @default.
• W1990396073 hasAuthorship W1990396073A5087503029 @default.
• W1990396073 hasAuthorship W1990396073A5091758834 @default.
• W1990396073 hasConcept C118552586 @default.
• W1990396073 hasConcept C126322002 @default.
• W1990396073 hasConcept C15744967 @default.
• W1990396073 hasConcept C2775870346 @default.
• W1990396073 hasConcept C2776412080 @default.
• W1990396073 hasConcept C2776619155 @default.
• W1990396073 hasConcept C2776921671 @default.
• W1990396073 hasConcept C2777270317 @default.
• W1990396073 hasConcept C2778775820 @default.
• W1990396073 hasConcept C2780057945 @default.
• W1990396073 hasConcept C2780494398 @default.
• W1990396073 hasConcept C2780634440 @default.
• W1990396073 hasConcept C2780688371 @default.
• W1990396073 hasConcept C2780777758 @default.
• W1990396073 hasConcept C2780864610 @default.
• W1990396073 hasConcept C2780948584 @default.
• W1990396073 hasConcept C2910202354 @default.
• W1990396073 hasConcept C513476851 @default.
• W1990396073 hasConcept C71924100 @default.
• W1990396073 hasConcept C98274493 @default.
• W1990396073 hasConceptScore W1990396073C118552586 @default.
• W1990396073 hasConceptScore W1990396073C126322002 @default.
• W1990396073 hasConceptScore W1990396073C15744967 @default.
• W1990396073 hasConceptScore W1990396073C2775870346 @default.
• W1990396073 hasConceptScore W1990396073C2776412080 @default.
• W1990396073 hasConceptScore W1990396073C2776619155 @default.
• W1990396073 hasConceptScore W1990396073C2776921671 @default.
• W1990396073 hasConceptScore W1990396073C2777270317 @default.
• W1990396073 hasConceptScore W1990396073C2778775820 @default.
• W1990396073 hasConceptScore W1990396073C2780057945 @default.
• W1990396073 hasConceptScore W1990396073C2780494398 @default.
• W1990396073 hasConceptScore W1990396073C2780634440 @default.
• W1990396073 hasConceptScore W1990396073C2780688371 @default.
• W1990396073 hasConceptScore W1990396073C2780777758 @default.
• W1990396073 hasConceptScore W1990396073C2780864610 @default.
• W1990396073 hasConceptScore W1990396073C2780948584 @default.
• W1990396073 hasConceptScore W1990396073C2910202354 @default.
• W1990396073 hasConceptScore W1990396073C513476851 @default.

• next