FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990397785> ?p ?o ?g. }

• W1990397785 endingPage "4914" @default.
• W1990397785 startingPage "4909" @default.
• W1990397785 abstract "Seven cell lines expressing native and transfected nicotinic receptor subtypes were evaluated functionally by using fluorescent assays based on membrane potential and calcium dynamics with “no-wash” dye systems. Both assays provided the same rank orders of potency for (±)-epibatidine, 2 S -(−)-nicotine, 7 R ,9 S -(−)-cytisine, and 1,1-dimethyl-4-phenylpiperazinium in a cell line expressing rat α3β4 receptors. Nicotinic antagonists mecamylamine and dihydro-β-erythroidine inhibited responses in both assays. Both agonist and antagonist activity were assessed within the same experiment. Agonists seemed more potent in the membrane potential assay than in the calcium assay, whereas the converse was true for antagonists. The membrane potential assay afforded robust responses in K-177 cells expressing human α4β2 receptors, in IMR-32 and SH-SY5Y cells expressing human ganglionic receptors, and in TE-671 cells expressing human neuromuscular receptors. These lines gave weak to modest calcium responses. Moreover, membrane potential responses were obtained in cell lines expressing rat α4β2 and α4β4 receptors, which were devoid of calcium responses. Thus, membrane potential serves as a sensitive measure of nicotinic activity, and the resulting depolarization may be as important as calcium in cell signaling." @default.
• W1990397785 created "2016-06-24" @default.
• W1990397785 creator A5006057012 @default.
• W1990397785 creator A5033483377 @default.
• W1990397785 creator A5043967898 @default.
• W1990397785 creator A5070605420 @default.
• W1990397785 date "2003-03-25" @default.
• W1990397785 modified "2023-10-11" @default.
• W1990397785 title "Membrane potential fluorescence: A rapid and highly sensitive assay for nicotinic receptor channel function" @default.
• W1990397785 cites W1492781998 @default.
• W1990397785 cites W1494500074 @default.
• W1990397785 cites W1601936385 @default.
• W1990397785 cites W1974125256 @default.
• W1990397785 cites W1983923219 @default.
• W1990397785 cites W1996024251 @default.
• W1990397785 cites W2002886847 @default.
• W1990397785 cites W2017175797 @default.
• W1990397785 cites W2023492178 @default.
• W1990397785 cites W2028335226 @default.
• W1990397785 cites W2032272710 @default.
• W1990397785 cites W2036216077 @default.
• W1990397785 cites W2038935287 @default.
• W1990397785 cites W2049084706 @default.
• W1990397785 cites W2049693868 @default.
• W1990397785 cites W2050917293 @default.
• W1990397785 cites W2055418337 @default.
• W1990397785 cites W2067503183 @default.
• W1990397785 cites W2081686317 @default.
• W1990397785 cites W2086808366 @default.
• W1990397785 cites W2098098632 @default.
• W1990397785 cites W2105822725 @default.
• W1990397785 cites W2123345036 @default.
• W1990397785 cites W2125229293 @default.
• W1990397785 cites W2135163605 @default.
• W1990397785 cites W2139787666 @default.
• W1990397785 cites W2141260882 @default.
• W1990397785 cites W2142745678 @default.
• W1990397785 cites W2187976670 @default.
• W1990397785 cites W2236820229 @default.
• W1990397785 cites W2238918217 @default.
• W1990397785 cites W2260895682 @default.
• W1990397785 cites W2276099977 @default.
• W1990397785 cites W2337485954 @default.
• W1990397785 cites W2339495421 @default.
• W1990397785 cites W2419490500 @default.
• W1990397785 cites W273322253 @default.
• W1990397785 doi "https://doi.org/10.1073/pnas.0630641100" @default.
• W1990397785 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/153654" @default.
• W1990397785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12657731" @default.
• W1990397785 hasPublicationYear "2003" @default.
• W1990397785 type Work @default.
• W1990397785 sameAs 1990397785 @default.
• W1990397785 citedByCount "95" @default.
• W1990397785 countsByYear W19903977852012 @default.
• W1990397785 countsByYear W19903977852013 @default.
• W1990397785 countsByYear W19903977852014 @default.
• W1990397785 countsByYear W19903977852015 @default.
• W1990397785 countsByYear W19903977852016 @default.
• W1990397785 countsByYear W19903977852017 @default.
• W1990397785 countsByYear W19903977852018 @default.
• W1990397785 countsByYear W19903977852019 @default.
• W1990397785 countsByYear W19903977852020 @default.
• W1990397785 countsByYear W19903977852021 @default.
• W1990397785 countsByYear W19903977852022 @default.
• W1990397785 countsByYear W19903977852023 @default.
• W1990397785 crossrefType "journal-article" @default.
• W1990397785 hasAuthorship W1990397785A5006057012 @default.
• W1990397785 hasAuthorship W1990397785A5033483377 @default.
• W1990397785 hasAuthorship W1990397785A5043967898 @default.
• W1990397785 hasAuthorship W1990397785A5070605420 @default.
• W1990397785 hasBestOaLocation W19903977851 @default.
• W1990397785 hasConcept C170493617 @default.
• W1990397785 hasConcept C181911157 @default.
• W1990397785 hasConcept C185592680 @default.
• W1990397785 hasConcept C188987157 @default.
• W1990397785 hasConcept C2776880047 @default.
• W1990397785 hasConcept C2777301948 @default.
• W1990397785 hasConcept C2909754679 @default.
• W1990397785 hasConcept C55493867 @default.
• W1990397785 hasConcept C86803240 @default.
• W1990397785 hasConcept C95444343 @default.
• W1990397785 hasConcept C98274493 @default.
• W1990397785 hasConceptScore W1990397785C170493617 @default.
• W1990397785 hasConceptScore W1990397785C181911157 @default.
• W1990397785 hasConceptScore W1990397785C185592680 @default.
• W1990397785 hasConceptScore W1990397785C188987157 @default.
• W1990397785 hasConceptScore W1990397785C2776880047 @default.
• W1990397785 hasConceptScore W1990397785C2777301948 @default.
• W1990397785 hasConceptScore W1990397785C2909754679 @default.
• W1990397785 hasConceptScore W1990397785C55493867 @default.
• W1990397785 hasConceptScore W1990397785C86803240 @default.
• W1990397785 hasConceptScore W1990397785C95444343 @default.
• W1990397785 hasConceptScore W1990397785C98274493 @default.
• W1990397785 hasIssue "8" @default.
• W1990397785 hasLocation W19903977851 @default.
• W1990397785 hasLocation W19903977852 @default.
• W1990397785 hasLocation W19903977853 @default.
• W1990397785 hasLocation W19903977854 @default.

• next