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- W1990397959 abstract "Transition state analogues of PNP, the Immucillins and DADMe−Immucillins, were designed to match transition state features of bovine and human PNPs, respectively. The inhibitors with or without the hydroxyl and hydroxymethyl groups of the substrate demonstrate that inhibitor geometry mimicking that of the transition state confers binding affinity discrimination. This finding is remarkable since crystallographic analysis indicates complete conservation of active site residues and contacts to ligands in human and bovine PNPs." @default.
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- W1990397959 date "2006-05-12" @default.
- W1990397959 modified "2023-10-02" @default.
- W1990397959 title "Transition State Analogue Discrimination by Related Purine Nucleoside Phosphorylases" @default.
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- W1990397959 doi "https://doi.org/10.1021/ja061403n" @default.
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