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- W1990400510 abstract "In this work, the cytotoxic effects of some spirostane derivatives were examined in cultured hepatocytes and V79 fibroblasts using different viability assays. The derivatives were obtained by modifying the A and B rings of diosgenin. Diosgenin and its derivatives were more toxic in V79 fibroblasts (IC 50 40-300 µM) than in hepatocytes (IC 50 280-1000 µM). Inhibition of cytochrome P450IIIA in cultured hepatocytes by incubation with 1 mM cimetidine did not alter the toxicity of these compounds in these cells. These observations suggest that other pathways of detoxification may be involved in hepatocytes. In conclusion, the compounds studied merit investigation for their potential pharmacological and industrial applicability." @default.
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- W1990400510 date "2004-10-01" @default.
- W1990400510 modified "2023-10-18" @default.
- W1990400510 title "Cytotoxicity of the phytosterol diosgenin and its derivatives in rat cultured hepatocytes and V79 fibroblasts" @default.
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- W1990400510 doi "https://doi.org/10.1191/0960327104ht474oa" @default.
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