FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990402565> ?p ?o ?g. }

• W1990402565 endingPage "7798" @default.
• W1990402565 startingPage "7794" @default.
• W1990402565 abstract "Surfactant protein B (SP-B) is an 8.7-kDa, hydrophobic protein that enhances the spreading and stability of surfactant phospholipids in the alveolus. To further assess the role of SP-B in lung function, the SP-B gene was disrupted by homologous recombination in murine mouse embryonic stem cells. Mice with a single mutated SP-B allele (+/-) were unaffected, whereas homozygous SP-B -/- offspring died of respiratory failure immediately after birth. Lungs of SP-B -/- mice developed normally but remained atelectatic in spite of postnatal respiratory efforts. SP-B protein and mRNA were undetectable and tubular myelin figures were lacking in SP-B -/- mice. Type II cells of SP-B -/- mice contained no fully formed lamellar bodies. While the abundance of SP-A and SP-C mRNAs was not altered, an aberrant form of pro-SP-C, 8.5 kDa, was detected, and fully processed SP-C peptide was markedly decreased in lung homogenates of SP-B -/- mice. Ablation of the SP-B gene disrupts the routing, storage, and function of surfactant phospholipids and proteins, causing respiratory failure at birth." @default.
• W1990402565 created "2016-06-24" @default.
• W1990402565 creator A5001813162 @default.
• W1990402565 creator A5016281271 @default.
• W1990402565 creator A5022754309 @default.
• W1990402565 creator A5040126408 @default.
• W1990402565 creator A5055786810 @default.
• W1990402565 creator A5062224123 @default.
• W1990402565 creator A5082463233 @default.
• W1990402565 date "1995-08-15" @default.
• W1990402565 modified "2023-10-16" @default.
• W1990402565 title "Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice." @default.
• W1990402565 cites W1975821342 @default.
• W1990402565 cites W1983451815 @default.
• W1990402565 cites W1994204296 @default.
• W1990402565 cites W1996421710 @default.
• W1990402565 cites W2000170431 @default.
• W1990402565 cites W2002859881 @default.
• W1990402565 cites W2004176673 @default.
• W1990402565 cites W2005472063 @default.
• W1990402565 cites W2015144647 @default.
• W1990402565 cites W2016434419 @default.
• W1990402565 cites W2019094071 @default.
• W1990402565 cites W2042180396 @default.
• W1990402565 cites W2046423422 @default.
• W1990402565 cites W2050842983 @default.
• W1990402565 cites W2062327206 @default.
• W1990402565 cites W2081202307 @default.
• W1990402565 cites W2093314252 @default.
• W1990402565 cites W2130703491 @default.
• W1990402565 cites W2159055946 @default.
• W1990402565 cites W2331089332 @default.
• W1990402565 cites W2398180612 @default.
• W1990402565 cites W2406269117 @default.
• W1990402565 cites W2411930589 @default.
• W1990402565 doi "https://doi.org/10.1073/pnas.92.17.7794" @default.
• W1990402565 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/41232" @default.
• W1990402565 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7644495" @default.
• W1990402565 hasPublicationYear "1995" @default.
• W1990402565 type Work @default.
• W1990402565 sameAs 1990402565 @default.
• W1990402565 citedByCount "592" @default.
• W1990402565 countsByYear W19904025652012 @default.
• W1990402565 countsByYear W19904025652013 @default.
• W1990402565 countsByYear W19904025652014 @default.
• W1990402565 countsByYear W19904025652015 @default.
• W1990402565 countsByYear W19904025652016 @default.
• W1990402565 countsByYear W19904025652017 @default.
• W1990402565 countsByYear W19904025652018 @default.
• W1990402565 countsByYear W19904025652019 @default.
• W1990402565 countsByYear W19904025652020 @default.
• W1990402565 countsByYear W19904025652021 @default.
• W1990402565 countsByYear W19904025652022 @default.
• W1990402565 countsByYear W19904025652023 @default.
• W1990402565 crossrefType "journal-article" @default.
• W1990402565 hasAuthorship W1990402565A5001813162 @default.
• W1990402565 hasAuthorship W1990402565A5016281271 @default.
• W1990402565 hasAuthorship W1990402565A5022754309 @default.
• W1990402565 hasAuthorship W1990402565A5040126408 @default.
• W1990402565 hasAuthorship W1990402565A5055786810 @default.
• W1990402565 hasAuthorship W1990402565A5062224123 @default.
• W1990402565 hasAuthorship W1990402565A5082463233 @default.
• W1990402565 hasBestOaLocation W19904025651 @default.
• W1990402565 hasConcept C104317684 @default.
• W1990402565 hasConcept C105702510 @default.
• W1990402565 hasConcept C136449434 @default.
• W1990402565 hasConcept C145156650 @default.
• W1990402565 hasConcept C153911025 @default.
• W1990402565 hasConcept C170493617 @default.
• W1990402565 hasConcept C2777438239 @default.
• W1990402565 hasConcept C534529494 @default.
• W1990402565 hasConcept C55493867 @default.
• W1990402565 hasConcept C58226133 @default.
• W1990402565 hasConcept C86803240 @default.
• W1990402565 hasConceptScore W1990402565C104317684 @default.
• W1990402565 hasConceptScore W1990402565C105702510 @default.
• W1990402565 hasConceptScore W1990402565C136449434 @default.
• W1990402565 hasConceptScore W1990402565C145156650 @default.
• W1990402565 hasConceptScore W1990402565C153911025 @default.
• W1990402565 hasConceptScore W1990402565C170493617 @default.
• W1990402565 hasConceptScore W1990402565C2777438239 @default.
• W1990402565 hasConceptScore W1990402565C534529494 @default.
• W1990402565 hasConceptScore W1990402565C55493867 @default.
• W1990402565 hasConceptScore W1990402565C58226133 @default.
• W1990402565 hasConceptScore W1990402565C86803240 @default.
• W1990402565 hasIssue "17" @default.
• W1990402565 hasLocation W19904025651 @default.
• W1990402565 hasLocation W19904025652 @default.
• W1990402565 hasLocation W19904025653 @default.
• W1990402565 hasLocation W19904025654 @default.
• W1990402565 hasOpenAccess W1990402565 @default.
• W1990402565 hasPrimaryLocation W19904025651 @default.
• W1990402565 hasRelatedWork W1831400781 @default.
• W1990402565 hasRelatedWork W1997055282 @default.
• W1990402565 hasRelatedWork W2055804265 @default.
• W1990402565 hasRelatedWork W2068517715 @default.
• W1990402565 hasRelatedWork W2073993023 @default.
• W1990402565 hasRelatedWork W2136062886 @default.

• next