Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990406618> ?p ?o ?g. }
Showing items 1 to 54 of
54
with 100 items per page.
- W1990406618 endingPage "S187" @default.
- W1990406618 startingPage "S186" @default.
- W1990406618 abstract "Recent reports have described some of the underlying components and mechanisms that contribute to the species barrier to retro/lentiviruses, and vectors derived from them. At least part of this blockade is thought to be due to restriction factors, which act to subvert incoming virions down non-replicative pathways. At high multiplicities of infection (MOI) such factors can be titrated away, allowing the cell to be transduced. Elsewhere it has been demonstrated that, similarly to HIV and MLV, Equine Infectious Anaemia virus (EIAV) vectors may also be restricted in a variety of cell types, including human cells. If true, this may have implications regarding EIAV vectors' utility for human gene therapy applications. We have developed highly engineered completely minimal EIAV vectors, and have demonstrated the vectors' potential in a number of pre-clinical models of human disease, including recent studies in models of Parkinson's disease and amyotrophic lateral sclerosis (ALS). We are currently developing the vector system and an associated bank of safety tests, as a prerequisite for treating Parkinson's disease in patients." @default.
- W1990406618 created "2016-06-24" @default.
- W1990406618 date "2005-05-01" @default.
- W1990406618 modified "2023-10-14" @default.
- W1990406618 title "481. Dynamics of Transduction of Human Cells by EIAV Vectors – The Importance of Cell Entry" @default.
- W1990406618 doi "https://doi.org/10.1016/j.ymthe.2005.07.021" @default.
- W1990406618 hasPublicationYear "2005" @default.
- W1990406618 type Work @default.
- W1990406618 sameAs 1990406618 @default.
- W1990406618 citedByCount "0" @default.
- W1990406618 crossrefType "journal-article" @default.
- W1990406618 hasBestOaLocation W19904066181 @default.
- W1990406618 hasConcept C121332964 @default.
- W1990406618 hasConcept C12554922 @default.
- W1990406618 hasConcept C145912823 @default.
- W1990406618 hasConcept C1491633281 @default.
- W1990406618 hasConcept C15152581 @default.
- W1990406618 hasConcept C159047783 @default.
- W1990406618 hasConcept C24890656 @default.
- W1990406618 hasConcept C54355233 @default.
- W1990406618 hasConcept C62478195 @default.
- W1990406618 hasConcept C86803240 @default.
- W1990406618 hasConcept C95444343 @default.
- W1990406618 hasConceptScore W1990406618C121332964 @default.
- W1990406618 hasConceptScore W1990406618C12554922 @default.
- W1990406618 hasConceptScore W1990406618C145912823 @default.
- W1990406618 hasConceptScore W1990406618C1491633281 @default.
- W1990406618 hasConceptScore W1990406618C15152581 @default.
- W1990406618 hasConceptScore W1990406618C159047783 @default.
- W1990406618 hasConceptScore W1990406618C24890656 @default.
- W1990406618 hasConceptScore W1990406618C54355233 @default.
- W1990406618 hasConceptScore W1990406618C62478195 @default.
- W1990406618 hasConceptScore W1990406618C86803240 @default.
- W1990406618 hasConceptScore W1990406618C95444343 @default.
- W1990406618 hasLocation W19904066181 @default.
- W1990406618 hasOpenAccess W1990406618 @default.
- W1990406618 hasPrimaryLocation W19904066181 @default.
- W1990406618 hasRelatedWork W1197377995 @default.
- W1990406618 hasRelatedWork W1487857142 @default.
- W1990406618 hasRelatedWork W1702322095 @default.
- W1990406618 hasRelatedWork W1865764402 @default.
- W1990406618 hasRelatedWork W1998016140 @default.
- W1990406618 hasRelatedWork W2144354735 @default.
- W1990406618 hasRelatedWork W2146376140 @default.
- W1990406618 hasRelatedWork W3146957265 @default.
- W1990406618 hasRelatedWork W3183075330 @default.
- W1990406618 hasRelatedWork W4319915726 @default.
- W1990406618 hasVolume "11" @default.
- W1990406618 isParatext "false" @default.
- W1990406618 isRetracted "false" @default.
- W1990406618 magId "1990406618" @default.
- W1990406618 workType "article" @default.