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- W1990408519 endingPage "120" @default.
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- W1990408519 abstract "Hepcidin/LEAP-1 is an iron regulatory hormone originally identified as an antimicrobial peptide. As part of a systematic analysis of the evolution of host defense peptides in primates, we have sequenced the orthologous gene from 14 species of non-human primates. The sequence of the mature peptide is highly conserved amongst all the analyzed species, being identical to the human one in great apes and gibbons, with a single residue conservative variation in Old-World monkeys and with few substitutions in New-World monkeys. Our analysis indicates that hepcidin's role as a regulatory hormone, which involves interaction with a conserved receptor (ferroportin), may result in conservation over most of its sequence, with the exception of the stretch between residues 15 and 18, which in New-World monkeys (as well as in other mammals) shows a significant variation, possibly indicating that this structural region is involved in other functions." @default.
- W1990408519 created "2016-06-24" @default.
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- W1990408519 date "2008-01-01" @default.
- W1990408519 modified "2023-10-06" @default.
- W1990408519 title "Evolution of the hepcidin gene in primates" @default.
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- W1990408519 doi "https://doi.org/10.1186/1471-2164-9-120" @default.
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