FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990408857> ?p ?o ?g. }

• W1990408857 endingPage "1228" @default.
• W1990408857 startingPage "1220" @default.
• W1990408857 abstract "Sulfation plays an obligatory role in the activation of N-hydroxy derivatives of carcinogenic aryl-amiric(amide)s and heterocyclic amines. We found that the hepatic sulfotransferase-mediated covalent binding of 3H-labeled 2-hydroxyamino-1-inethy1-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP) to calf thymus DNA was 3.3 and 12.9 times higher with human cytosol preparation than with male and female rat cytosol preparations, respectively, in the presence of 3’-phosphnadenosine 5’-phospho-sulfate. To assess the activating capacities of individual phenol-sulfating sulfotransferascs, five different forms, human ST1A2 and ST1A3 and rat ST1A1, ST1B1 and ST1C1, were expressed in heterologous cells. All five sulfotransferases mediated the activation of N-OH-PhIP to DNA-bound products. The extents of the binding, however, differed considerably among these forms. Human ST1A2 and ST1A3 mediated the activation of N-OH-PhIP at 5.2- and 6.2-fold higher rates than did rat ST1C1, a main N-hydroxy-2-acetylaminofluorene-activating sulfotransferase, in rat liver. Extents of the binding of N-OH-PhIP in human hepatic cytosols of different individuals were positively correlated with the contents of immunoreactive ST1A2/3. These results suggest a potential role of human liver sulfotransferases in N-OH-PhIP activation. In contrast, the low sulfotransferase-mediated activation of N-OH-PhIP in rat liver is consistent with the lack of PhIP hepatocarcino-genicity in this species." @default.
• W1990408857 created "2016-06-24" @default.
• W1990408857 creator A5007422276 @default.
• W1990408857 creator A5025885052 @default.
• W1990408857 creator A5030517670 @default.
• W1990408857 creator A5055723769 @default.
• W1990408857 creator A5069722397 @default.
• W1990408857 creator A5087771359 @default.
• W1990408857 date "1994-12-01" @default.
• W1990408857 modified "2023-10-11" @default.
• W1990408857 title "Activation of 2-Hydroxyamino-l-methyl-6-phenylimidazo[4,5-<i>b</i>]pyridne by cDNA-expressed Human and Rat Arylsulfotransferases" @default.
• W1990408857 cites W1516726110 @default.
• W1990408857 cites W1963349111 @default.
• W1990408857 cites W1968108283 @default.
• W1990408857 cites W1971525258 @default.
• W1990408857 cites W1977157092 @default.
• W1990408857 cites W1977381688 @default.
• W1990408857 cites W1984505053 @default.
• W1990408857 cites W1985053175 @default.
• W1990408857 cites W1990906823 @default.
• W1990408857 cites W1995096842 @default.
• W1990408857 cites W2006081103 @default.
• W1990408857 cites W2012062618 @default.
• W1990408857 cites W2014352349 @default.
• W1990408857 cites W2016591484 @default.
• W1990408857 cites W2016661553 @default.
• W1990408857 cites W2028585500 @default.
• W1990408857 cites W2040127734 @default.
• W1990408857 cites W2050409908 @default.
• W1990408857 cites W2056799965 @default.
• W1990408857 cites W2060031216 @default.
• W1990408857 cites W2068497261 @default.
• W1990408857 cites W2093483447 @default.
• W1990408857 cites W2105891424 @default.
• W1990408857 cites W2123050076 @default.
• W1990408857 cites W2148805603 @default.
• W1990408857 cites W2210000121 @default.
• W1990408857 cites W2280568339 @default.
• W1990408857 cites W2415572035 @default.
• W1990408857 cites W2419640921 @default.
• W1990408857 doi "https://doi.org/10.1111/j.1349-7006.1994.tb02933.x" @default.
• W1990408857 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5919400" @default.
• W1990408857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7852185" @default.
• W1990408857 hasPublicationYear "1994" @default.
• W1990408857 type Work @default.
• W1990408857 sameAs 1990408857 @default.
• W1990408857 citedByCount "74" @default.
• W1990408857 countsByYear W19904088572012 @default.
• W1990408857 countsByYear W19904088572013 @default.
• W1990408857 countsByYear W19904088572014 @default.
• W1990408857 countsByYear W19904088572018 @default.
• W1990408857 countsByYear W19904088572021 @default.
• W1990408857 countsByYear W19904088572023 @default.
• W1990408857 crossrefType "journal-article" @default.
• W1990408857 hasAuthorship W1990408857A5007422276 @default.
• W1990408857 hasAuthorship W1990408857A5025885052 @default.
• W1990408857 hasAuthorship W1990408857A5030517670 @default.
• W1990408857 hasAuthorship W1990408857A5055723769 @default.
• W1990408857 hasAuthorship W1990408857A5069722397 @default.
• W1990408857 hasAuthorship W1990408857A5087771359 @default.
• W1990408857 hasBestOaLocation W19904088571 @default.
• W1990408857 hasConcept C114246631 @default.
• W1990408857 hasConcept C153911025 @default.
• W1990408857 hasConcept C155138218 @default.
• W1990408857 hasConcept C181199279 @default.
• W1990408857 hasConcept C185592680 @default.
• W1990408857 hasConcept C2775904581 @default.
• W1990408857 hasConcept C552990157 @default.
• W1990408857 hasConcept C55493867 @default.
• W1990408857 hasConcept C71240020 @default.
• W1990408857 hasConcept C86803240 @default.
• W1990408857 hasConcept C98539663 @default.
• W1990408857 hasConceptScore W1990408857C114246631 @default.
• W1990408857 hasConceptScore W1990408857C153911025 @default.
• W1990408857 hasConceptScore W1990408857C155138218 @default.
• W1990408857 hasConceptScore W1990408857C181199279 @default.
• W1990408857 hasConceptScore W1990408857C185592680 @default.
• W1990408857 hasConceptScore W1990408857C2775904581 @default.
• W1990408857 hasConceptScore W1990408857C552990157 @default.
• W1990408857 hasConceptScore W1990408857C55493867 @default.
• W1990408857 hasConceptScore W1990408857C71240020 @default.
• W1990408857 hasConceptScore W1990408857C86803240 @default.
• W1990408857 hasConceptScore W1990408857C98539663 @default.
• W1990408857 hasIssue "12" @default.
• W1990408857 hasLocation W19904088571 @default.
• W1990408857 hasLocation W19904088572 @default.
• W1990408857 hasLocation W19904088573 @default.
• W1990408857 hasLocation W19904088574 @default.
• W1990408857 hasOpenAccess W1990408857 @default.
• W1990408857 hasPrimaryLocation W19904088571 @default.
• W1990408857 hasRelatedWork W1554639627 @default.
• W1990408857 hasRelatedWork W1592774805 @default.
• W1990408857 hasRelatedWork W1969969188 @default.
• W1990408857 hasRelatedWork W1993043588 @default.
• W1990408857 hasRelatedWork W1996756647 @default.
• W1990408857 hasRelatedWork W2005034578 @default.
• W1990408857 hasRelatedWork W2022077270 @default.
• W1990408857 hasRelatedWork W2166951703 @default.

• next