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- W1990409377 abstract "African American men have the highest incidence of prostate cancer in the world and have substantially higher rates of prostate cancer when compared to white men in the U.S. The cause(s) for this race disparity remains elusive. A single nucleotide polymorphism (SNP), rs10486567, in intron 2 of juxtaposed with another zinc finger protein 1 (JAZF1) has been associated with increased risk of prostate cancer in genome-wide association studies (GWAS) and may be key to uncovering reasons for disparities in the disease. JAZF1 is a cysteine-hystidine structured zinc finger protein, a type of protein that has been shown to interact with lead in vitro. Lead is recognized as a probable carcinogen in humans and African American men who are residentially segregated to industrialized urban environments in the U.S. have higher blood lead levels on average compared to white men. In a case-only study of 228 African American men with prostate cancer diagnosed at a large health system in the Detroit Metropolitan area, we assessed gene-environment interactions (GxE) between rs10486567 (CC vs. CT/TT genotype) and two sources of lead exposure. Lifetime occupational lead exposure was determined through industrial hygiene review of extensive face-to-face interviews. Neighborhood lead exposure, defined as the median proportion of census tract housing built before 1950 (≥ 47% vs. Citation Information: Cancer Epidemiol Biomarkers Prev 2010;19(10 Suppl):PR-8." @default.
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- W1990409377 date "2010-10-01" @default.
- W1990409377 modified "2023-09-25" @default.
- W1990409377 title "Abstract PR-8: Gene-environment interactions between JAZF1 and occupational and neighborhood lead exposure in African American prostate cancer cases" @default.
- W1990409377 doi "https://doi.org/10.1158/1055-9965.disp-10-pr-10" @default.
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