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- W1990410325 startingPage "395" @default.
- W1990410325 abstract "Sexually reproducing animals require an orchestrated communication between spermatozoa and the egg to generate a new individual. Capacitation, a maturational complex phenomenon that occurs in the female reproductive tract, renders spermatozoa capable of binding and fusing with the oocyte, and it is a requirement for mammalian fertilization. Capacitation encompasses plasma membrane reorganization, ion permeability regulation, cholesterol loss and changes in the phosphorylation state of many proteins. Novel tools to study sperm ion channels, image intracellular ionic changes and proteins with better spatial and temporal resolution, are unraveling how modifications in sperm ion transport and phosphorylation states lead to capacitation. Recent evidence indicates that two parallel pathways regulate phosphorylation events leading to capacitation, one of them requiring activation of protein kinase A and the second one involving inactivation of ser/thr phosphatases. This review examines the involvement of ion transporters and phosphorylation signaling processes needed for spermatozoa to achieve capacitation. Understanding the molecular mechanisms leading to fertilization is central for societies to deal with rising male infertility rates, to develop safe male gamete-based contraceptives and to preserve biodiversity through better assisted fertilization strategies." @default.
- W1990410325 created "2016-06-24" @default.
- W1990410325 creator A5011954284 @default.
- W1990410325 creator A5017497606 @default.
- W1990410325 creator A5031178522 @default.
- W1990410325 creator A5033068410 @default.
- W1990410325 creator A5076420296 @default.
- W1990410325 date "2011-05-01" @default.
- W1990410325 modified "2023-10-16" @default.
- W1990410325 title "Ion channels, phosphorylation and mammalian sperm capacitation" @default.
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