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- W1990411503 abstract "The role of nutrition and balanced metabolism in normal growth, development, and health maintenance is well known. Patients affected with either acute or chronic diseases often show disorders of nutrient balance. In some cases, a devastating state of malnutrition known as cachexia arises, brought about by a synergistic combination of a dramatic decrease in appetite and an increase in metabolism of fat and lean body mass. Other common features that are not required for the diagnosis include decreases in voluntary movement, insulin resistance, and anhedonia. This combination is found in a number of disorders including cancer, cystic fibrosis, AIDS, rheumatoid arthritis, renal failure, and Alzheimer's disease. The severity of cachexia in these illnesses is often the primary determining factor in both quality of life, and in eventual mortality. Indeed, body mass retention in AIDS patients has a stronger association with survival than any other current measure of the disease. This has led to intense investigation of cachexia and the proposal of numerous hypotheses regarding its etiology. Most authors suggest that cytokines released during inflammation and malignancy act on the central nervous system to alter the release and function of a number of neurotransmitters, thereby altering both appetite and metabolic rate. This review will discuss the salient features of cachexia in human diseases, and review the mechanisms whereby inflammation alters the function of key brain regions to produce stereotypical illness behavior. The paper represents an invited review by a symposium, award winner or keynote speaker at the Society for the Study of Ingestive Behavior [SSIB] Annual Meeting in Portland, July 2009." @default.
- W1990411503 created "2016-06-24" @default.
- W1990411503 creator A5000850327 @default.
- W1990411503 creator A5042273601 @default.
- W1990411503 creator A5045078700 @default.
- W1990411503 date "2010-07-01" @default.
- W1990411503 modified "2023-10-03" @default.
- W1990411503 title "Hypothalamic mechanisms in cachexia" @default.
- W1990411503 cites W1525267985 @default.
- W1990411503 cites W1529067373 @default.
- W1990411503 cites W1563952748 @default.
- W1990411503 cites W1578219376 @default.
- W1990411503 cites W1603808379 @default.
- W1990411503 cites W1790206216 @default.
- W1990411503 cites W1838662971 @default.
- W1990411503 cites W1900191186 @default.
- W1990411503 cites W1960422292 @default.
- W1990411503 cites W1964368905 @default.
- W1990411503 cites W1964557416 @default.
- W1990411503 cites W1964846273 @default.
- W1990411503 cites W1965044262 @default.
- W1990411503 cites W1966035579 @default.
- W1990411503 cites W1967497010 @default.
- W1990411503 cites W1970552222 @default.
- W1990411503 cites W1971051809 @default.
- W1990411503 cites W1971295330 @default.
- W1990411503 cites W1971446180 @default.
- W1990411503 cites W1973434266 @default.
- W1990411503 cites W1974573366 @default.
- W1990411503 cites W1976456818 @default.
- W1990411503 cites W1976584924 @default.
- W1990411503 cites W1977114413 @default.
- W1990411503 cites W1977219742 @default.
- W1990411503 cites W1977385652 @default.
- W1990411503 cites W1978485246 @default.
- W1990411503 cites W1979467063 @default.
- W1990411503 cites W1981025527 @default.
- W1990411503 cites W1982387056 @default.
- W1990411503 cites W1982509198 @default.
- W1990411503 cites W1982778215 @default.
- W1990411503 cites W1983839833 @default.
- W1990411503 cites W1984982968 @default.
- W1990411503 cites W1985315724 @default.
- W1990411503 cites W1985534077 @default.
- W1990411503 cites W1985663362 @default.
- W1990411503 cites W1990119407 @default.
- W1990411503 cites W1992782580 @default.
- W1990411503 cites W1996150740 @default.
- W1990411503 cites W1996476319 @default.
- W1990411503 cites W1996713062 @default.
- W1990411503 cites W1999710695 @default.
- W1990411503 cites W1999866182 @default.
- W1990411503 cites W2001660140 @default.
- W1990411503 cites W2002190250 @default.
- W1990411503 cites W2002624552 @default.
- W1990411503 cites W2003064100 @default.
- W1990411503 cites W2003867612 @default.
- W1990411503 cites W2008200661 @default.
- W1990411503 cites W2008310054 @default.
- W1990411503 cites W2008499673 @default.
- W1990411503 cites W2008661951 @default.
- W1990411503 cites W2009762469 @default.
- W1990411503 cites W2012496594 @default.
- W1990411503 cites W2012509713 @default.
- W1990411503 cites W2012707242 @default.
- W1990411503 cites W2014484891 @default.
- W1990411503 cites W2015148943 @default.
- W1990411503 cites W2015535527 @default.
- W1990411503 cites W2015774467 @default.
- W1990411503 cites W2015804704 @default.
- W1990411503 cites W2017709986 @default.
- W1990411503 cites W2017990338 @default.
- W1990411503 cites W2018931269 @default.
- W1990411503 cites W2020647896 @default.
- W1990411503 cites W2020678121 @default.
- W1990411503 cites W2021460276 @default.
- W1990411503 cites W2022047640 @default.
- W1990411503 cites W2022979746 @default.
- W1990411503 cites W2023299675 @default.
- W1990411503 cites W2024734221 @default.
- W1990411503 cites W2025467727 @default.
- W1990411503 cites W2025846514 @default.
- W1990411503 cites W2026192447 @default.
- W1990411503 cites W2027427622 @default.
- W1990411503 cites W2030171828 @default.
- W1990411503 cites W2031204178 @default.
- W1990411503 cites W2031850022 @default.
- W1990411503 cites W2032091078 @default.
- W1990411503 cites W2032820751 @default.
- W1990411503 cites W2033218360 @default.
- W1990411503 cites W2033764884 @default.
- W1990411503 cites W2035121795 @default.
- W1990411503 cites W2037280691 @default.
- W1990411503 cites W2037584745 @default.
- W1990411503 cites W2037751427 @default.
- W1990411503 cites W2038297164 @default.
- W1990411503 cites W2039016375 @default.
- W1990411503 cites W2040901874 @default.