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- W1990419694 abstract "To gain an understanding of molecular events that underlie pattern formation in the retina, we evaluated the expression profiles of over 8000 transcripts randomly selected from an embryonic zebrafish library. Detailed analysis of cDNAs that display restricted expression patterns revealed factors that are specifically expressed in single cell classes and are potential regulators of neurogenesis. These cDNAs belong to numerous molecular categories and include cell surface receptors, cytoplasmic enzymes, and transcription factors. To test whether expression patterns that we have uncovered using this approach are indicative of function in neurogenesis, we used morpholino-mediated knockdown approach. The knockdown of soxp, a transcript expressed in the vicinity of the inner plexiform layer, revealed its role in cell type composition of amacrine and ganglion cell layers. Blocking the function of cxcr4b, a chemokine receptor specifically expressed in ganglion cells, suggests a role in ganglion cell survival. These experiments demonstrate that in situ hybridization-based reverse genetic screens can be applied to isolate genetic regulators of neurogenesis. This approach very well complements forward genetic mutagenesis studies previously used to study retinal neurogenesis in zebrafish." @default.
- W1990419694 created "2016-06-24" @default.
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- W1990419694 date "2006-05-01" @default.
- W1990419694 modified "2023-10-16" @default.
- W1990419694 title "Reverse genetic analysis of neurogenesis in the zebrafish retina" @default.
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- W1990419694 cites W1555420746 @default.
- W1990419694 cites W1587435244 @default.
- W1990419694 cites W1827800528 @default.
- W1990419694 cites W1895565798 @default.
- W1990419694 cites W1902196155 @default.
- W1990419694 cites W190835940 @default.
- W1990419694 cites W1959046600 @default.
- W1990419694 cites W1968802624 @default.
- W1990419694 cites W1971563525 @default.
- W1990419694 cites W1972383232 @default.
- W1990419694 cites W1972757014 @default.
- W1990419694 cites W1973776426 @default.
- W1990419694 cites W1974264340 @default.
- W1990419694 cites W1975016685 @default.
- W1990419694 cites W1975786425 @default.
- W1990419694 cites W1976880781 @default.
- W1990419694 cites W1977284325 @default.
- W1990419694 cites W1979632020 @default.
- W1990419694 cites W1979756417 @default.
- W1990419694 cites W1983319708 @default.
- W1990419694 cites W1988744406 @default.
- W1990419694 cites W1990779469 @default.
- W1990419694 cites W1994254814 @default.
- W1990419694 cites W1998272605 @default.
- W1990419694 cites W1998756807 @default.
- W1990419694 cites W2000498893 @default.
- W1990419694 cites W2000643824 @default.
- W1990419694 cites W2006249044 @default.
- W1990419694 cites W2012750970 @default.
- W1990419694 cites W2013851169 @default.
- W1990419694 cites W2016983168 @default.
- W1990419694 cites W2018180871 @default.
- W1990419694 cites W2020575571 @default.
- W1990419694 cites W2023262022 @default.
- W1990419694 cites W2028517758 @default.
- W1990419694 cites W2030913774 @default.
- W1990419694 cites W2035222904 @default.
- W1990419694 cites W2036631473 @default.
- W1990419694 cites W2036921369 @default.
- W1990419694 cites W2039278255 @default.
- W1990419694 cites W2041598409 @default.
- W1990419694 cites W2045439534 @default.
- W1990419694 cites W2048501294 @default.
- W1990419694 cites W2049279317 @default.
- W1990419694 cites W2055985491 @default.
- W1990419694 cites W2061122481 @default.
- W1990419694 cites W2064139298 @default.
- W1990419694 cites W2073222527 @default.
- W1990419694 cites W2079269655 @default.
- W1990419694 cites W2080937698 @default.
- W1990419694 cites W2082401415 @default.
- W1990419694 cites W2083612980 @default.
- W1990419694 cites W2083898995 @default.
- W1990419694 cites W2084699385 @default.
- W1990419694 cites W2089202414 @default.
- W1990419694 cites W2089256321 @default.
- W1990419694 cites W2096379390 @default.
- W1990419694 cites W2098509726 @default.
- W1990419694 cites W2103062633 @default.
- W1990419694 cites W2109652663 @default.
- W1990419694 cites W2112355295 @default.
- W1990419694 cites W2113176895 @default.
- W1990419694 cites W2126057356 @default.
- W1990419694 cites W2134209856 @default.
- W1990419694 cites W2136010410 @default.
- W1990419694 cites W2136656087 @default.
- W1990419694 cites W2141735759 @default.
- W1990419694 cites W2142101377 @default.
- W1990419694 cites W2145147271 @default.
- W1990419694 cites W2148050076 @default.
- W1990419694 cites W2148305274 @default.
- W1990419694 cites W2148415574 @default.
- W1990419694 cites W2154831201 @default.
- W1990419694 cites W2159083156 @default.
- W1990419694 cites W2164386538 @default.
- W1990419694 cites W2166663391 @default.
- W1990419694 cites W2167027593 @default.
- W1990419694 cites W2169529166 @default.
- W1990419694 cites W2187732153 @default.
- W1990419694 cites W4296811057 @default.
- W1990419694 cites W2148153412 @default.
- W1990419694 doi "https://doi.org/10.1016/j.ydbio.2005.12.056" @default.
- W1990419694 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16603149" @default.
- W1990419694 hasPublicationYear "2006" @default.
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