FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990427208> ?p ?o ?g. }

• W1990427208 endingPage "e62476" @default.
• W1990427208 startingPage "e62476" @default.
• W1990427208 abstract "In Drosophila melanogaster, genes of the sex-determination hierarchy orchestrate the development and differentiation of sex-specific tissues, establishing sex-specific physiology and neural circuitry. One of these sex-determination genes, fruitless (fru), plays a key role in the formation of neural circuits underlying Drosophila male courtship behavior. Conservation of fru gene structure and sex-specific expression has been found in several insect orders, though it is still to be determined whether a male courtship role for the gene is employed in these species due to the lack of mutants and homologous experimental evidence. We have isolated the fru ortholog (Md-fru) from the common housefly, Musca domestica, and show the gene’s conserved genomic structure. We demonstrate that male-specific Md-fru transcripts arise by conserved mechanisms of sex-specific splicing. Here we show that Md-fru, is similarly involved in controlling male courtship behavior. A male courtship behavioral function for Md-fru was revealed by the behavioral and neuroanatomical analyses of a hypomorphic allele, Md-traman, which specifically disrupted the expression of Md-fru in males, leading to severely impaired male courtship behavior. In line with a role in nervous system development, we found that expression of Md-fru was confined to neural tissues in the brain, most prominently in optic neuropil and in peripheral sensory organs. We propose that, like in Drosophila, overt sexual differentiation of the housefly depends on a sex-determining pathway that bifurcates downstream of the Md-tra gene to coordinate dimorphic development of non-neuronal tissues mediated by Md-dsx with that of neuronal tissues largely mediated by Md-fru." @default.
• W1990427208 created "2016-06-24" @default.
• W1990427208 creator A5000044000 @default.
• W1990427208 creator A5053600787 @default.
• W1990427208 creator A5056591889 @default.
• W1990427208 creator A5069554741 @default.
• W1990427208 creator A5071427419 @default.
• W1990427208 creator A5088302274 @default.
• W1990427208 date "2013-04-22" @default.
• W1990427208 modified "2023-10-03" @default.
• W1990427208 title "Genetic Control of Courtship Behavior in the Housefly: Evidence for a Conserved Bifurcation of the Sex-Determining Pathway" @default.
• W1990427208 cites W1481867552 @default.
• W1990427208 cites W1508218767 @default.
• W1990427208 cites W1543392118 @default.
• W1990427208 cites W1880904118 @default.
• W1990427208 cites W1916841507 @default.
• W1990427208 cites W1929625280 @default.
• W1990427208 cites W1952958388 @default.
• W1990427208 cites W1991089608 @default.
• W1990427208 cites W2000048948 @default.
• W1990427208 cites W2002766516 @default.
• W1990427208 cites W2004515777 @default.
• W1990427208 cites W2014908429 @default.
• W1990427208 cites W2019165844 @default.
• W1990427208 cites W2019678396 @default.
• W1990427208 cites W2019811699 @default.
• W1990427208 cites W2023186350 @default.
• W1990427208 cites W2026108361 @default.
• W1990427208 cites W2032176996 @default.
• W1990427208 cites W2037147108 @default.
• W1990427208 cites W2039568017 @default.
• W1990427208 cites W2043126077 @default.
• W1990427208 cites W2050609151 @default.
• W1990427208 cites W2051937150 @default.
• W1990427208 cites W2052886690 @default.
• W1990427208 cites W2058735778 @default.
• W1990427208 cites W2061058091 @default.
• W1990427208 cites W2066008662 @default.
• W1990427208 cites W2071168337 @default.
• W1990427208 cites W2073201794 @default.
• W1990427208 cites W2076241630 @default.
• W1990427208 cites W2077178820 @default.
• W1990427208 cites W2082397632 @default.
• W1990427208 cites W2082827942 @default.
• W1990427208 cites W2083225071 @default.
• W1990427208 cites W2090551154 @default.
• W1990427208 cites W2091511780 @default.
• W1990427208 cites W2100309727 @default.
• W1990427208 cites W2106466943 @default.
• W1990427208 cites W2110447200 @default.
• W1990427208 cites W2117463629 @default.
• W1990427208 cites W2128269277 @default.
• W1990427208 cites W2134212197 @default.
• W1990427208 cites W2137012989 @default.
• W1990427208 cites W2138421255 @default.
• W1990427208 cites W2138814742 @default.
• W1990427208 cites W2147362216 @default.
• W1990427208 cites W2147411450 @default.
• W1990427208 cites W2149736186 @default.
• W1990427208 cites W2157159187 @default.
• W1990427208 cites W2159041612 @default.
• W1990427208 cites W2159571381 @default.
• W1990427208 cites W2160745947 @default.
• W1990427208 cites W2165687893 @default.
• W1990427208 cites W2167194725 @default.
• W1990427208 cites W2334186905 @default.
• W1990427208 doi "https://doi.org/10.1371/journal.pone.0062476" @default.
• W1990427208 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3632534" @default.
• W1990427208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23630634" @default.
• W1990427208 hasPublicationYear "2013" @default.
• W1990427208 type Work @default.
• W1990427208 sameAs 1990427208 @default.
• W1990427208 citedByCount "31" @default.
• W1990427208 countsByYear W19904272082013 @default.
• W1990427208 countsByYear W19904272082014 @default.
• W1990427208 countsByYear W19904272082015 @default.
• W1990427208 countsByYear W19904272082017 @default.
• W1990427208 countsByYear W19904272082018 @default.
• W1990427208 countsByYear W19904272082019 @default.
• W1990427208 countsByYear W19904272082020 @default.
• W1990427208 countsByYear W19904272082021 @default.
• W1990427208 countsByYear W19904272082022 @default.
• W1990427208 countsByYear W19904272082023 @default.
• W1990427208 crossrefType "journal-article" @default.
• W1990427208 hasAuthorship W1990427208A5000044000 @default.
• W1990427208 hasAuthorship W1990427208A5053600787 @default.
• W1990427208 hasAuthorship W1990427208A5056591889 @default.
• W1990427208 hasAuthorship W1990427208A5069554741 @default.
• W1990427208 hasAuthorship W1990427208A5071427419 @default.
• W1990427208 hasAuthorship W1990427208A5088302274 @default.
• W1990427208 hasBestOaLocation W19904272081 @default.
• W1990427208 hasConcept C104317684 @default.
• W1990427208 hasConcept C130039590 @default.
• W1990427208 hasConcept C169760540 @default.
• W1990427208 hasConcept C173758957 @default.
• W1990427208 hasConcept C182049041 @default.
• W1990427208 hasConcept C18903297 @default.
• W1990427208 hasConcept C2776453541 @default.

• next