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- W199043405 abstract "This chapter highlights the significant advances in brain delivery of peptide and protein drugs made over the past three decades. While many limitations still exist regarding the cerebral delivery of peptide and protein drugs, several strategies show considerable promise for improvement of brain uptake. The chapter reviews the various strategies that are applicable for enhancing the delivery of protein/peptide delivery to the CNS. A wide variety of peptides and proteins have been identified as promising therapeutic agents for the treatment of various brain pathologies. Peptides and proteins are present in the whole nervous system, with unique distribution patterns. They can exert numerous biological actions in the brain, such as regulation of the internal environment of the brain and of the cerebral blood flow; modulation of the permeability of the blood–brain barrier (BBB) to nutrients, neurotransmission, and neuromodulation; various roles in the immune system; and hormonal regulation in the endocrine system. They are also involved in temperature control; food and water intake; cardiovascular, gastrointestinal, and respiratory control; memory and affective states; and potently modulate nerve development and regeneration. The multiplicity of biological actions of peptides suggests that these agents may be used as pharmaceuticals in the treatment of a variety of disorders of the brain and spinal cord, as indeed is borne out in the examples provided in this chapter." @default.
- W199043405 created "2016-06-24" @default.
- W199043405 creator A5025442498 @default.
- W199043405 date "2011-01-01" @default.
- W199043405 modified "2023-10-12" @default.
- W199043405 title "Brain Delivery of Peptides and Proteins" @default.
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- W199043405 doi "https://doi.org/10.1016/b978-0-12-384935-9.10006-9" @default.
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