Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990442983> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W1990442983 endingPage "277" @default.
- W1990442983 startingPage "269" @default.
- W1990442983 abstract "The influence of the lincosamide antibiotic, clindamycin, on the properties of bullfrog sympathetic ganglion B cells has been determined in vitro using conventional voltage recording methods or single microelectrode voltage-clamp recording techniques. Individual neurons were depolarized with both bath application or local perfusion of clindamycin. The amplitude of the depolarization was not altered by pretreatment with 50 microM (+)-tubocurarine, 10-microM atropine, or 1.5 microM tetrodotoxin (TTX), indicating that the clindamycin-induced depolarization does not result from either the activation of (1) nicotinic receptors, (2) muscarinic receptors, or (3) voltage-gated sodium channels. Clindamycin partially inhibited IM, an action which accounts for part of the clindamycin-induced depolarization. The duration of the hyperpolarizing afterpotential (HAP) following the action potential was decreased in the presence of clindamycin. Clindamycin decreased the amplitude and maximum rate of rise (MRR) of TTX-insensitive action potentials. As calcium influx is thought to contribute to the depolarizing phase of the TTX-insensitive spikes, we suggest that the decrease in HAP duration by clindamycin results from a decrease in the somal calcium current. Further, it is suggested that a decrease in IM and HAP duration may be responsible for the increased excitability exhibited during exposure to clindamycin." @default.
- W1990442983 created "2016-06-24" @default.
- W1990442983 creator A5031429272 @default.
- W1990442983 creator A5070648908 @default.
- W1990442983 date "1988-08-01" @default.
- W1990442983 modified "2023-10-16" @default.
- W1990442983 title "Clindamycin-induced alteration of ganglionic function. I. Direct effects on ganglion cell properties" @default.
- W1990442983 cites W1851102264 @default.
- W1990442983 cites W1974260774 @default.
- W1990442983 cites W1980313328 @default.
- W1990442983 cites W1982921362 @default.
- W1990442983 cites W1983835859 @default.
- W1990442983 cites W1998008685 @default.
- W1990442983 cites W2003573775 @default.
- W1990442983 cites W2009588136 @default.
- W1990442983 cites W2025699017 @default.
- W1990442983 cites W2034036946 @default.
- W1990442983 cites W2055044206 @default.
- W1990442983 cites W2059690890 @default.
- W1990442983 cites W2070283619 @default.
- W1990442983 cites W2077323356 @default.
- W1990442983 cites W2080786780 @default.
- W1990442983 cites W2082178747 @default.
- W1990442983 cites W2083701641 @default.
- W1990442983 cites W2086068542 @default.
- W1990442983 cites W2087267768 @default.
- W1990442983 cites W2088909679 @default.
- W1990442983 cites W2095905298 @default.
- W1990442983 cites W2124257402 @default.
- W1990442983 cites W2132927696 @default.
- W1990442983 cites W2159333738 @default.
- W1990442983 doi "https://doi.org/10.1016/0006-8993(88)90469-6" @default.
- W1990442983 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3264742" @default.
- W1990442983 hasPublicationYear "1988" @default.
- W1990442983 type Work @default.
- W1990442983 sameAs 1990442983 @default.
- W1990442983 citedByCount "6" @default.
- W1990442983 countsByYear W19904429832018 @default.
- W1990442983 countsByYear W19904429832019 @default.
- W1990442983 crossrefType "journal-article" @default.
- W1990442983 hasAuthorship W1990442983A5031429272 @default.
- W1990442983 hasAuthorship W1990442983A5070648908 @default.
- W1990442983 hasConcept C112592302 @default.
- W1990442983 hasConcept C12554922 @default.
- W1990442983 hasConcept C169760540 @default.
- W1990442983 hasConcept C170493617 @default.
- W1990442983 hasConcept C185592680 @default.
- W1990442983 hasConcept C2776741303 @default.
- W1990442983 hasConcept C2777458120 @default.
- W1990442983 hasConcept C2777646271 @default.
- W1990442983 hasConcept C4141045 @default.
- W1990442983 hasConcept C501593827 @default.
- W1990442983 hasConcept C55493867 @default.
- W1990442983 hasConcept C71924100 @default.
- W1990442983 hasConcept C86803240 @default.
- W1990442983 hasConcept C98274493 @default.
- W1990442983 hasConceptScore W1990442983C112592302 @default.
- W1990442983 hasConceptScore W1990442983C12554922 @default.
- W1990442983 hasConceptScore W1990442983C169760540 @default.
- W1990442983 hasConceptScore W1990442983C170493617 @default.
- W1990442983 hasConceptScore W1990442983C185592680 @default.
- W1990442983 hasConceptScore W1990442983C2776741303 @default.
- W1990442983 hasConceptScore W1990442983C2777458120 @default.
- W1990442983 hasConceptScore W1990442983C2777646271 @default.
- W1990442983 hasConceptScore W1990442983C4141045 @default.
- W1990442983 hasConceptScore W1990442983C501593827 @default.
- W1990442983 hasConceptScore W1990442983C55493867 @default.
- W1990442983 hasConceptScore W1990442983C71924100 @default.
- W1990442983 hasConceptScore W1990442983C86803240 @default.
- W1990442983 hasConceptScore W1990442983C98274493 @default.
- W1990442983 hasIssue "2" @default.
- W1990442983 hasLocation W19904429831 @default.
- W1990442983 hasLocation W19904429832 @default.
- W1990442983 hasOpenAccess W1990442983 @default.
- W1990442983 hasPrimaryLocation W19904429831 @default.
- W1990442983 hasRelatedWork W2011889469 @default.
- W1990442983 hasRelatedWork W2036435436 @default.
- W1990442983 hasRelatedWork W2064891429 @default.
- W1990442983 hasRelatedWork W2066909217 @default.
- W1990442983 hasRelatedWork W2073806994 @default.
- W1990442983 hasRelatedWork W2166618203 @default.
- W1990442983 hasRelatedWork W2187871674 @default.
- W1990442983 hasRelatedWork W2256350618 @default.
- W1990442983 hasRelatedWork W2410372181 @default.
- W1990442983 hasRelatedWork W2412375860 @default.
- W1990442983 hasVolume "458" @default.
- W1990442983 isParatext "false" @default.
- W1990442983 isRetracted "false" @default.
- W1990442983 magId "1990442983" @default.
- W1990442983 workType "article" @default.