Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990443648> ?p ?o ?g. }
- W1990443648 endingPage "3070" @default.
- W1990443648 startingPage "3059" @default.
- W1990443648 abstract "Excess retinoic acid (RA) during pregnancy can cause various developmental anomalies in both humans and rodents. We investigated the mechanisms underlying the aberrant differentiation of tongue muscles in fetal mice exposed to exogenous RA in utero. RA-degrading enzymes (Cyp26a1 and Cyp26b1) were expressed at early stages of normal tongue development, but exogenous RA perturbed their expression in the fetal tongue. RA is normally distributed in the developing tongue muscles but its localization was disrupted by exogenous RA. After RA treatment, myogenic determination factors were reduced and the differentiation was significantly suppressed in tongue muscles. Tbx1, a candidate gene of DiGeorge syndrome, was down-regulated in the fetal tongue in response to excess RA. Moreover, Tbx1 as well as myogenic determination factors were not observed in tongue muscle primordia of Cyp26b1−/− fetuses. Our study suggests that RA signaling may play an essential role in tongue muscle differentiation via the regulation of Tbx1. Developmental Dynamics 237:3059–3070, 2008. © 2008 Wiley-Liss, Inc." @default.
- W1990443648 created "2016-06-24" @default.
- W1990443648 creator A5023449645 @default.
- W1990443648 creator A5043070213 @default.
- W1990443648 creator A5059191212 @default.
- W1990443648 date "2008-09-24" @default.
- W1990443648 modified "2023-10-18" @default.
- W1990443648 title "Retinoic acid down-regulates Tbx1 expression and induces abnormal differentiation of tongue muscles in fetal mice" @default.
- W1990443648 cites W1501608538 @default.
- W1990443648 cites W1527331090 @default.
- W1990443648 cites W1573772505 @default.
- W1990443648 cites W1841957993 @default.
- W1990443648 cites W1971045517 @default.
- W1990443648 cites W1983318886 @default.
- W1990443648 cites W1988917710 @default.
- W1990443648 cites W1990786422 @default.
- W1990443648 cites W1990789332 @default.
- W1990443648 cites W2001642371 @default.
- W1990443648 cites W2005883936 @default.
- W1990443648 cites W2007081540 @default.
- W1990443648 cites W2011156134 @default.
- W1990443648 cites W2017313377 @default.
- W1990443648 cites W2022088761 @default.
- W1990443648 cites W2026279127 @default.
- W1990443648 cites W2035075164 @default.
- W1990443648 cites W2036912330 @default.
- W1990443648 cites W2038639188 @default.
- W1990443648 cites W2041710680 @default.
- W1990443648 cites W2045620427 @default.
- W1990443648 cites W2049863096 @default.
- W1990443648 cites W2063694492 @default.
- W1990443648 cites W2081372952 @default.
- W1990443648 cites W2085511966 @default.
- W1990443648 cites W2086345206 @default.
- W1990443648 cites W2091644785 @default.
- W1990443648 cites W2098841171 @default.
- W1990443648 cites W2112731799 @default.
- W1990443648 cites W2114919588 @default.
- W1990443648 cites W2117511712 @default.
- W1990443648 cites W2135934912 @default.
- W1990443648 cites W2136971004 @default.
- W1990443648 cites W2145896384 @default.
- W1990443648 cites W2148011592 @default.
- W1990443648 cites W2148680251 @default.
- W1990443648 cites W2148922553 @default.
- W1990443648 cites W2156684099 @default.
- W1990443648 cites W2157304951 @default.
- W1990443648 cites W2164648160 @default.
- W1990443648 cites W2165108884 @default.
- W1990443648 cites W2166256370 @default.
- W1990443648 cites W4212811418 @default.
- W1990443648 doi "https://doi.org/10.1002/dvdy.21715" @default.
- W1990443648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18816858" @default.
- W1990443648 hasPublicationYear "2008" @default.
- W1990443648 type Work @default.
- W1990443648 sameAs 1990443648 @default.
- W1990443648 citedByCount "27" @default.
- W1990443648 countsByYear W19904436482012 @default.
- W1990443648 countsByYear W19904436482013 @default.
- W1990443648 countsByYear W19904436482014 @default.
- W1990443648 countsByYear W19904436482015 @default.
- W1990443648 countsByYear W19904436482016 @default.
- W1990443648 countsByYear W19904436482018 @default.
- W1990443648 countsByYear W19904436482019 @default.
- W1990443648 countsByYear W19904436482020 @default.
- W1990443648 countsByYear W19904436482021 @default.
- W1990443648 countsByYear W19904436482022 @default.
- W1990443648 countsByYear W19904436482023 @default.
- W1990443648 crossrefType "journal-article" @default.
- W1990443648 hasAuthorship W1990443648A5023449645 @default.
- W1990443648 hasAuthorship W1990443648A5043070213 @default.
- W1990443648 hasAuthorship W1990443648A5059191212 @default.
- W1990443648 hasBestOaLocation W19904436481 @default.
- W1990443648 hasConcept C101762097 @default.
- W1990443648 hasConcept C104317684 @default.
- W1990443648 hasConcept C126322002 @default.
- W1990443648 hasConcept C134018914 @default.
- W1990443648 hasConcept C142724271 @default.
- W1990443648 hasConcept C150194340 @default.
- W1990443648 hasConcept C172680121 @default.
- W1990443648 hasConcept C2779234561 @default.
- W1990443648 hasConcept C2779744641 @default.
- W1990443648 hasConcept C2781121885 @default.
- W1990443648 hasConcept C54355233 @default.
- W1990443648 hasConcept C68473852 @default.
- W1990443648 hasConcept C71924100 @default.
- W1990443648 hasConcept C86803240 @default.
- W1990443648 hasConcept C95444343 @default.
- W1990443648 hasConceptScore W1990443648C101762097 @default.
- W1990443648 hasConceptScore W1990443648C104317684 @default.
- W1990443648 hasConceptScore W1990443648C126322002 @default.
- W1990443648 hasConceptScore W1990443648C134018914 @default.
- W1990443648 hasConceptScore W1990443648C142724271 @default.
- W1990443648 hasConceptScore W1990443648C150194340 @default.
- W1990443648 hasConceptScore W1990443648C172680121 @default.
- W1990443648 hasConceptScore W1990443648C2779234561 @default.
- W1990443648 hasConceptScore W1990443648C2779744641 @default.
- W1990443648 hasConceptScore W1990443648C2781121885 @default.