Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990451812> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1990451812 endingPage "2676" @default.
- W1990451812 startingPage "2671" @default.
- W1990451812 abstract "GH receptor (GHR) has been reported to express in both normal rat and human adrenals. However, no study examined GHR expression in diseased human adrenal cortex. We quantitated, with RT-PCR, GHR messenger RNA (mRNA) in both normal and diseased human adrenal cortex with the following results: GHR mRNA levels in four histologically normal, not steroid-stimulated, control adrenal cortices was 1.5–11 × 104 molecules/μg total RNA; in three diffusely hyperplastic adrenals (DH): 6.7–17.7 × 104; in two nonfunctioning tumors (NF): 0.84–1.9 × 104; in five androgen-producing neoplasms (AP): 4.6–34 × 104; and in five glucocorticoid-producing neoplasms (GP): 6.7–87 × 104. GHR transcript levels among adrenal cortices, DH, NF, AP, and GP reached statistically significant difference (P < 0.03). The GP group exhibited higher GHR mRNA levels than controls (P < 0.006). NF, as well as GP and AP, tumors had less GHR mRNA than their histologically normal adjacent cortex (P < 0.05). A positive correlation between urinary cortisol and GHR messenger RNA (mRNA) levels from GP and DH was observed (r = 0.93, P < 0.003). Our data suggest that GHR is expressed in both normal and diseased adrenal cortex and that GHR mRNA accumulation is less efficient in adrenocortical neoplasm than their adjacent nonneoplastic cortex. GHR expression in adrenal cortex provides an evidence of direct GH action in this tissue." @default.
- W1990451812 created "2016-06-24" @default.
- W1990451812 creator A5008550885 @default.
- W1990451812 creator A5009429782 @default.
- W1990451812 creator A5011058812 @default.
- W1990451812 creator A5029571636 @default.
- W1990451812 creator A5047451026 @default.
- W1990451812 creator A5050438302 @default.
- W1990451812 date "1997-08-01" @default.
- W1990451812 modified "2023-10-18" @default.
- W1990451812 title "Growth Hormone Receptor Messenger Ribonucleic Acid in Normal and Pathologic Human Adrenocortical Tissues—An Analysis by Quantitative Polymerase Chain Reaction Technique1" @default.
- W1990451812 cites W1966969669 @default.
- W1990451812 cites W1973151550 @default.
- W1990451812 cites W1993013017 @default.
- W1990451812 cites W2000446241 @default.
- W1990451812 cites W2014305135 @default.
- W1990451812 cites W2024901631 @default.
- W1990451812 cites W2033456201 @default.
- W1990451812 cites W2044524102 @default.
- W1990451812 cites W2050853712 @default.
- W1990451812 cites W2061753579 @default.
- W1990451812 cites W2089728262 @default.
- W1990451812 cites W2093754217 @default.
- W1990451812 cites W2130222325 @default.
- W1990451812 cites W2149897099 @default.
- W1990451812 cites W2161488480 @default.
- W1990451812 cites W2335977314 @default.
- W1990451812 cites W4294216491 @default.
- W1990451812 doi "https://doi.org/10.1210/jcem.82.8.4159" @default.
- W1990451812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9253352" @default.
- W1990451812 hasPublicationYear "1997" @default.
- W1990451812 type Work @default.
- W1990451812 sameAs 1990451812 @default.
- W1990451812 citedByCount "7" @default.
- W1990451812 countsByYear W19904518122014 @default.
- W1990451812 countsByYear W19904518122015 @default.
- W1990451812 crossrefType "journal-article" @default.
- W1990451812 hasAuthorship W1990451812A5008550885 @default.
- W1990451812 hasAuthorship W1990451812A5009429782 @default.
- W1990451812 hasAuthorship W1990451812A5011058812 @default.
- W1990451812 hasAuthorship W1990451812A5029571636 @default.
- W1990451812 hasAuthorship W1990451812A5047451026 @default.
- W1990451812 hasAuthorship W1990451812A5050438302 @default.
- W1990451812 hasBestOaLocation W19904518121 @default.
- W1990451812 hasConcept C104317684 @default.
- W1990451812 hasConcept C105580179 @default.
- W1990451812 hasConcept C113675107 @default.
- W1990451812 hasConcept C126322002 @default.
- W1990451812 hasConcept C134018914 @default.
- W1990451812 hasConcept C170493617 @default.
- W1990451812 hasConcept C2777911890 @default.
- W1990451812 hasConcept C2777977426 @default.
- W1990451812 hasConcept C2780841215 @default.
- W1990451812 hasConcept C2984496839 @default.
- W1990451812 hasConcept C55493867 @default.
- W1990451812 hasConcept C59493245 @default.
- W1990451812 hasConcept C67705224 @default.
- W1990451812 hasConcept C71315377 @default.
- W1990451812 hasConcept C71924100 @default.
- W1990451812 hasConcept C86803240 @default.
- W1990451812 hasConceptScore W1990451812C104317684 @default.
- W1990451812 hasConceptScore W1990451812C105580179 @default.
- W1990451812 hasConceptScore W1990451812C113675107 @default.
- W1990451812 hasConceptScore W1990451812C126322002 @default.
- W1990451812 hasConceptScore W1990451812C134018914 @default.
- W1990451812 hasConceptScore W1990451812C170493617 @default.
- W1990451812 hasConceptScore W1990451812C2777911890 @default.
- W1990451812 hasConceptScore W1990451812C2777977426 @default.
- W1990451812 hasConceptScore W1990451812C2780841215 @default.
- W1990451812 hasConceptScore W1990451812C2984496839 @default.
- W1990451812 hasConceptScore W1990451812C55493867 @default.
- W1990451812 hasConceptScore W1990451812C59493245 @default.
- W1990451812 hasConceptScore W1990451812C67705224 @default.
- W1990451812 hasConceptScore W1990451812C71315377 @default.
- W1990451812 hasConceptScore W1990451812C71924100 @default.
- W1990451812 hasConceptScore W1990451812C86803240 @default.
- W1990451812 hasIssue "8" @default.
- W1990451812 hasLocation W19904518121 @default.
- W1990451812 hasLocation W19904518122 @default.
- W1990451812 hasOpenAccess W1990451812 @default.
- W1990451812 hasPrimaryLocation W19904518121 @default.
- W1990451812 hasRelatedWork W1975968177 @default.
- W1990451812 hasRelatedWork W1999156064 @default.
- W1990451812 hasRelatedWork W2015569104 @default.
- W1990451812 hasRelatedWork W2034583712 @default.
- W1990451812 hasRelatedWork W2071337848 @default.
- W1990451812 hasRelatedWork W2092107317 @default.
- W1990451812 hasRelatedWork W2109154705 @default.
- W1990451812 hasRelatedWork W2276893008 @default.
- W1990451812 hasRelatedWork W2414846389 @default.
- W1990451812 hasRelatedWork W4232773839 @default.
- W1990451812 hasVolume "82" @default.
- W1990451812 isParatext "false" @default.
- W1990451812 isRetracted "false" @default.
- W1990451812 magId "1990451812" @default.
- W1990451812 workType "article" @default.